El Potencial de la Hidroxiapatita Dopada como Sensor Termoluminiscente de Radiación ionizante

Ortiz, Susana López; Rodríguez-Lugo, Ventura; Villaseñor-Cerón, Lesly Sabina; Reyes-Valderrama, María Isabel; Salado-Leza, Daniela; Mendoza-Anaya, D.

doi:10.29057/icbi.v8iespecial.6310

Cited by 3 publications

(1 citation statement)

References 20 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the stable monoclinic obtained nanostructured HAp might be used in the well-known hard tissue replacement and reconstruction applications. Other applications include drug delivery [45], cell culture, antibodies purification at large scale [46], cell activation, CO 2 gas sensing, catalysis, and water treatment with efficient results [47,48].…”

Section: Discussionmentioning

confidence: 99%

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

et al. 2021

Self Cite

View full text Add to dashboard Cite

Hydroxyapatite (HAp) is a natural hard tissue constituent widely used for bone and tooth replacement engineering. In the present work, synthetic HAp was obtained from calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) and ammonium phosphate dibasic (NH4)2HPO4 following an optimized microwave assisted hydrothermal method. The effect of pH was evaluated by the addition of ammonium hydroxide (NH4OH). Hence, different characterization techniques were used to determine its influence on the resulted HAp powders’ size, shape, and crystallinity. By Transmission Electron Microscopy (TEM), it was observed that the reaction pH environment modifies the morphology of HAp, and a shape evolution, from sub-hedral particles at pH = 7 to rod-like nanosized HAp at pH = 10, was confirmed. Using the X-ray Diffraction (XRD) technique, the characteristic diffraction peaks of the monoclinic phase were identified. Even if the performed Rietveld analysis indicated the presence of both phases (hexagonal and monoclinic), monoclinic HAp prevails in 95% with an average crystallite size of about 23 nm. The infrared spectra (FTIR) showed absorption bands at 3468 cm−1 and 630 cm−1 associated with OH− of hydroxyapatite, and bands at 584 cm−1, 960 cm−1, and 1090 cm−1 that correspond to the PO43− and CO32− characteristic groups. In summary, this work contributes to obtaining nanosized rod-like monoclinic HAp by a simple and soft method that has not been previously reported.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Dy2O3-unpurified hydroxyapatite: a promising thermoluminescent sensor and biomimetic nanotherapeutic

et al. 2021

View full text Add to dashboard Cite

Biocompatibility analysis and chemical characterization of Mn-doped hydroxyapatite

Villaseñor-Cerón

Mendoza-Anaya

López-Ortiz

et al. 2023

J Mater Sci: Mater Med

Self Cite

View full text Add to dashboard Cite

The present work studies the effect of Mn doping on the crystalline structure of the Hap synthesized by the hydrothermal method at 200 °C for 24 h, from Ca(OH)2 and (NH4)2HPO4, incorporating MnCl2 to 0.1, 0.5, 1.0, 1.5 and 2.0 %wt of Mn concentrations. Samples were characterized by the X-Ray Diffraction technique, which revealed the diffraction peaks that corresponded to the hexagonal and monoclinic phase of the Hap; it was observed that the average size of crystallite decreased from 23.67 to 22.69 nm as the concentration of Mn increased. TEM shows that in all samples, there are two distributions of particle sizes; one corresponds to nanorods with several tens of nanometers in length, and the other in which the diameter and length are very close. FTIR analysis revealed absorption bands corresponding to the PO4−3 and OH− groups characteristic of the Hap. It was possible to establish a substitution mechanism between the Mn and the ions of Ca+2 of the Hap. From the Alamar blue test, a cell viability of 86.88% ± 5 corresponding to the sample of Hap at 1.5 %wt Mn was obtained, considered non-cytotoxic according to ISO 10993-5. It also evaluated and demonstrated the good osteoinductive properties of the materials, which were verified by histology and immunofluorescence expression of osteogenic markers. Adhesion, viability, biocompatibility and osteoinductive properties, make these materials candidates for future applications in bone tissue engineering with likely uses in regenerative medicine. Graphical Abstract

show abstract

El Potencial de la Hidroxiapatita Dopada como Sensor Termoluminiscente de Radiación ionizante

Cited by 3 publications

References 20 publications

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

Modulated Monoclinic Hydroxyapatite: The Effect of pH in the Microwave Assisted Method

Dy2O3-unpurified hydroxyapatite: a promising thermoluminescent sensor and biomimetic nanotherapeutic

Biocompatibility analysis and chemical characterization of Mn-doped hydroxyapatite

Contact Info

Product

Resources

About