El neumococo: ¿un germen nuevo en el recién nacido?

Romero, Concepción de Alba; Castillo, Espinoza

doi:10.1016/s1695-4033(01)77547-9

Cited by 10 publications

(3 citation statements)

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“…The risk factors related to infection by SP in newborns are premature rupture of membranes, prematurity, neonatal pneumonia with early presentation (<72 hours), and vaginal delivery (the risk factor most frequently associated) [4]. For this reason, despite the low frequency of SP as a cause of neonatal illness, it is important to consider this microorganism among the agents of sepsis in newborns.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the pathogenesis of invasive infection of the newborn by SP, the major role has been attributed to vertical transmission associated with maternal vaginal carriage and/or endometritis [2][3][4][5][6][7]. Through molecular biology studies, the clonal transmission of the bacteria from mother to child has been verified [5,8].…”

Section: Discussionmentioning

confidence: 99%

“…Recorded cases of neonatal sepsis are relatively few, with a described incidence between 1% and 11% [2]. The clinical manifestations during the neonatal period do not differ from those presented by other bacteria such as Streptococcus agalactiae and Escherichia coli, but S. pneumoniae presents higher morbidity and mortality, described as up to 50% [2][3][4].…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Early-Onset Neonatal Pneumococcal Sepsis: An Old but Sometimes Forgotten Pathogen

Coelho¹,

Baptista²,

Ramalho³

et al. 2022

Cureus

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Streptococcus pneumoniae (SP) is an uncommon but potentially serious neonatal pathogen. SP is perceived as a significant cause of mortality and morbidity in infancy; however, there are relatively few cases of neonatal sepsis recorded, with an incidence between 1% and 11%. We aim to report the spectrum of morbidity associated with SP infections in the neonatal period.Two cases of neonatal SP infection are reported. The first neonate presented with a very early onset of severe clinical disease with bacteremia and pneumonia. She developed severe pulmonary hypertension and needed intensive ventilatory support, including nitric oxide, and vasoactive drugs. An SP serotype 23B was isolated from blood cultures and bronchial secretions as well as from the mother's vaginal secretions. In the second case, the baby presented with bacteremia and meningitis. He remained hemodynamically stable and did not need respiratory support. Blood and cerebrospinal fluid cultures revealed an SP serotype 8. In both cases, the neonates were treated with vancomycin and cefotaxime. Both mothers remained well and asymptomatic during the perinatal period.These reported cases emphasize the importance of considering a wide range of microorganisms in the differential diagnosis of early-onset neonatal sepsis. Although uncommon, SP can have different clinical manifestations and cause significant diseases in newborns. Specific preventive measures against early-onset sepsis for this pathogen are yet to be implemented due to the absence of sufficient scientific evidence. For this reason, prompt and aggressive treatment remains the best therapeutic approach.

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Section: Discussionmentioning

confidence: 99%