El modelo de 6-hidroxidopamina y la fisiopatología parkinsoniana: nuevos hallazgos en un viejo modelo

Hernández-Baltazar, Daniel; Zavala-Flores, Laura; Villanueva-Olivo, Arnulfo

doi:10.1016/j.nrl.2015.06.011

Cited by 85 publications

(15 citation statements)

References 81 publications

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“…PD is characterized by progressive death of dopamine-containing neurons in the SNc. The striatal injection of the neurotoxin 6-OHDA leads to a progressive nigrostriatal dopaminergic pathway degeneration, mimicking human PD [ 65 , 66 ]. In our work, propolis mitigated 6-OHDA-induced loss of TH-positive nigrostriatal dopaminergic neurons.…”

Section: Discussionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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Patients with Parkinson’s disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor features. Nutrition is a key modifiable determinant of chronic disease. This study aimed to assess the effects of propolis on cardiological features, heart rate (HR) and heart rate variability (HRV) and on nigrostriatal dopaminergic damage, detected by tyrosine hydroxylase (TH) immunoreactivity, in the 6-hydroxydopamine (6-OHDA) rat model of PD. Male Wistar rats were injected bilaterally with 6-OHDA or saline into the striatum and were treated with propolis or water for 40 days. Autonomic function was assessed by time domain parameters (standard deviation of all normal-to-normal intervals (SDNN) and square root of the mean of the squared differences between adjacent normal RR intervals (RMSSD)) of HRV calculated from electrocardiogram recordings. Reductions in HR (p = 1.47 × 10−19), SDNN (p = 3.42 × 10−10) and RMSSD (p = 8.2 × 10−6) detected in parkinsonian rats were reverted by propolis. Propolis attenuated neuronal loss in the substantia nigra (p = 5.66 × 10−15) and reduced striatal fiber degeneration (p = 7.4 × 10−5) in 6-OHDA-injured rats, which also showed significant weight gain (p = 1.07 × 10−5) in comparison to 6-OHDA-lesioned counterparts. Propolis confers cardioprotection and neuroprotection in the 6-OHDA rat model of PD.

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Section: Discussionmentioning

confidence: 99%

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

et al. 2020

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“…In order to simulate the release of NE in the gastrointestinal tract during trauma, this study established an animal model that achieves a large release of NE by intraperitoneal injection of 6-OHDA. 6-OHDA selectively kills dopaminergic neurons and is a neurotoxic agent that does not cross the blood-brain barrier during peripheral application [ 22 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor

Meng

Chen

et al. 2020

Med Sci Monit

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Background We aimed to investigate the effects of norepinephrine (NE) released from endogenous stores on bacterial translocation of Escherichia coli in mice by administration of 6-hydroxydopamine (6-OHDA), which selectively destroys noradrenergic nerve terminals. Material/Methods E. coli strain BW25113 and its derivatives (BW25113Δ qseC and BW25113Δ qseC pQseC) were used in this study. The serum concentrations of endotoxin were analyzed. The strains BW25113, BW25113Δ qseC , and BW25113Δ qseC pQseC were detected respectively in tissue specimens harvested from mice treated with 6-OHDA. Results Mice treated with BW25113Δ qseC showed reduced levels of bacterial translocation following administration of 6-OHDA compared with mice treated with BW25113. The defect of E. coli QseC receptor caused the norepinephrine-QseC signal chain to be interrupted, and the invasiveness and penetrating power of the bacteria on the intestinal mucosa was weakened, eventually leading to a significant decrease in the incidence of bacterial translocation. Conclusions NE modulates the interaction of enteric bacterial pathogens with their hosts via QseC. The blockade of the QseC receptor-mediated effects may be useful to attenuate bacterial translocation.

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“…Paraquat is epidemiologically linked to PD (Tanner et al, 2011) and increased susceptibility to this pesticide could be determined in iPSC PD neurons (Ryan et al, 2013;Lin et al, 2016). 6-OHDA is a synthetic neurotoxin, taken up via the dopamine transporter and selectively damaging DA neurons due to ROS generation (Hernandez-Baltazar et al, 2017). An increased vulnerability of PD patients' derived neurons towards 6-OHDA has been determined (Nguyen et al, 2011;Lin et al, 2016).…”

Section: Stressor Responsementioning

confidence: 99%

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models

Simmnacher

Lanfer

Rizo

et al. 2020

Front. Cell. Neurosci.

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Parkinson's disease (PD) is the most frequently occurring movement disorder, with an increasing incidence due to an aging population. For many years, the post-mortem brain was regarded as the gold standard for the analysis of the human pathology of this disease. However, modern stem cell technologies, including the analysis of patient-specific neurons and glial cells, have opened up new avenues for dissecting the pathologic mechanisms of PD. Most data on morphological changes, such as cell death or changes in neurite complexity, or functional deficits were acquired in 2D and few in 3D models. This review will examine the prerequisites for human disease modeling in PD, covering the generation of midbrain neurons, 3D organoid midbrain models, the selection of controls including genetically engineered lines, and the study of cell-cell interactions. We will present major disease phenotypes in human in vitro models of PD, focusing on those phenotypes that have been detected in genetic and sporadic PD models. An additional point covered in this review will be the use of induced pluripotent stem cell (iPSC)-derived technologies to model cell-cell interactions in PD.

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El modelo de 6-hidroxidopamina y la fisiopatología parkinsoniana: nuevos hallazgos en un viejo modelo

Cited by 85 publications

References 81 publications

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models

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