El gradiente socioeconómico de la mortalidad por tuberculosis en México (2004-2008)

Meza-Palmeros, José Alejandro; Sánchez-Pérez, Héctor Javier; Freyermuth-Enciso, Graciela; Ramírez, Georgina Sánchez

doi:10.15517/psm.v10i2.8515

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Once the GMNP-AFB complex is formed, GMNPs facilitate rapid detection due to the presence of visually observable clumped red-stained bacilli which are surrounded by brown nanoparticles. This technique could be easily integrated into conventional TB control programs in any resource-limited setting and where SSM has low sensitivity performance [15,16,17,18,19,20,21,22,23]. The assay relies on the physical (magnetic) and chemical (glycan) properties of the nanoparticles to concentrate mycobacteria cells from clinical samples.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis

et al. 2018

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A new method using a magnetic nanoparticle-based colorimetric biosensing assay (NCBA) was compared with sputum smear microscopy (SSM) for the detection of pulmonary tuberculosis (PTB) in sputum samples. Studies were made to compare the NCBA against SSM using sputum samples collected from PTB patients prior to receiving treatment. Experiments were also conducted to determine the appropriate concentration of glycan-functionalized magnetic nanoparticles (GMNP) used in the NCBA and to evaluate the optimal digestion/decontamination solution to increase the extraction, concentration and detection of acid-fast bacilli (AFB). The optimized NCBA consisted of a 1:1 mixture of 0.4% NaOH and 4% N-acetyl-L-cysteine (NALC) to homogenize the sputum sample. Additionally, 10 mg/mL of GMNP was added to isolate and concentrate the AFB. All TB positive sputum samples were identified with an increased AFB count of 47% compared to SSM, demonstrating GMNP’s ability to extract and concentrate AFB. Results showed that NCBA increased AFB count compared to SSM, improving the grade from “1+” (in SSM) to “2+”. Extending the finding to paucibacillary cases, there is the likelihood of a “scant” grade to become “1+”. The assay uses a simple magnet and only costs $0.10/test. NCBA has great potential application in TB control programs.

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Section: Introductionmentioning

confidence: 99%

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis

et al. 2018

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“…In Chiapas, Indigenous People usually live under conditions of overcrowding, poverty, high levels of malnutrition, scarce access to health services, and little knowledge of the disease, which makes them more susceptible to contracting and developing TB [28,29], and having difficulties to comply with the anti-tuberculosis treatment, even when DOTS is provided in the region, just as the results of this study show.…”

Section: Discussionmentioning

confidence: 87%

Sociodemographic factors associated with the success or failure of anti-tuberculosis treatment in the Chiapas Highlands, Mexico, 2019–2022

Sánchez-Pérez,

Gordillo-Marroquín,

Vázquez-Marcelín

et al. 2024

PLoS ONE

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Objective To estimate the incidence rate of tuberculosis (TB) in the Highlands (Tsotsil-Tseltal) region of Chiapas and to analyze sociodemographic factors that might influence the success of anti-TB treatment from the period of January 2019 to June 2022. Methods Retrospective study in which the TB databases of the National Epidemiological Surveillance System (SINAVE) were analyzed. TB incidence rates were calculated based on the number of registered TB cases and estimated annual populations. The success-failure of anti-TB treatment was analyzed according to sociodemographic indicators, degree of concentration of indigenous population of the municipality of residence and admission to SINAVE. Results Two hundred thirty-three cases were analyzed. The variables associated to a lower success rate of treatment against TB were: living in a municipality with high-very high concentration of indigenous population, being indigenous, having a primary school education or lower, and agricultural occupation. The number of TB diagnosed from 2020–2022 and the incidence rates from 2020–2021 decreased significantly compared to 2019. Conclusions It is necessary to strengthen the follow-up of TB cases in the region, mainly in areas with high-very high indigenous concentration, in people with low levels of education and engaged in agricultural work.

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“…Sin embargo, la estrategia DOTS no fue del todo efectiva, debido a que no todos los gobiernos garantizaron plenamente que se cumplieran sus cinco componentes, además de que no contemplaba las dificultades de acceso económico de los pacientes -por ejemplo, en transporte-ni las dificultades culturales o lingüísticas para acceder a un diagnóstico oportuno, así como tampoco consideraba la alta posibilidad de que personas con TB fuesen estigmatizadas, por lo que muchos pacientes con esta enfermedad no eran diagnosticados, o lo eran tardíamente (22), o bien no se podía llevar a cabo de manera adecuada su tratamiento vía la estrategia DOTS (23). Un ejemplo que ilustra dicha situación es la elevada tasa de incidencia anual de TB-MDR en Perú, caso que, además de los factores socioeconómicos citados, debería llevar a reflexionar sobre las insuficiencias y disfunciones de los servicios de salud en la prevención y control de la TB.…”

Section: Tuberculosis En América Latina Y El Caribe Inequidad En El Acceso a Los Servicios De Saludunclassified

Tuberculosis en América Latina y el Caribe: reflexiones desde la bioética

et al. 2018

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El objetivo de este artículo es analizar las condiciones de acceso a servicios de salud de las personas con tuberculosis en América Latina y el Caribe (ALC), reflexionando desde la bioética sobre los aspectos de salud pública implicados. Se realizó una revisión documental del contexto de la tuberculosis en ALC con base en datos epidemiológicos. Los resultados se analizaron a partir de su relación con los determinantes sociales de la salud, los principios éticos que pautan la práctica médica y la responsabilidad social de los actores de salud. La tuberculosis es un problema de salud pública acuciante en la región, debido a su impacto familiar, comunitario, social, económico y sanitario, que afecta principalmente a personas y poblaciones vulneradas. En ALC la tuberculosis constituye un serio problema ético y de salud pública que causa un significativo número de muertes, discapacidad e incremento de la pobreza. La comprensión de su responsabilidad social por parte de los actores de salud es imperativa para cumplir con el derecho a servicios de salud de calidad, que aseguren un diagnóstico oportuno y un tratamiento completo de la enfermedad, y que guarden los principios de justicia, no discriminación y dignidad de los/las enfermos/as, para lo cual es importante que las estrategias nacionales de control de la tuberculosis incluyan cambios en los determinantes sociales de la enfermedad, así como el respeto de la etnia, cultura, lengua e identidad de los pacientes.

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El gradiente socioeconómico de la mortalidad por tuberculosis en México (2004-2008)

Abstract: El gradiente socioeconómico de la mortalidad por tuberculosis en México (2004-2008) The socioeconomic gradient in Tuberculosis mortality in Mexico (2004-2008

Cited by 4 publications

References 19 publications

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis

Sociodemographic factors associated with the success or failure of anti-tuberculosis treatment in the Chiapas Highlands, Mexico, 2019–2022

Tuberculosis en América Latina y el Caribe: reflexiones desde la bioética

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