El diagnóstico molecular en la praxis de la oncología en el Sector Salud. El laboratorio de oncología molecular como herramienta

Abstract

Las enfermedades on­cológicas son la tercera causa de morbimortalidad en México y afectan predominantemente al grupo de po­blación adulta. El cáncer corresponde a un proceso patológico individua­lizado de gran complejidad que se desarrolla en un microambiente ce­lular…

The genetic era of childhood cancer: Identification of high‐risk patients and germline sequencing approaches

“…Second, there are few laboratories that meet the international regulations of institutions such as The College of American Pathologist, CAP or The American College of Medical Genetics and Genomics, ACMG, and third, the number of available FDA approved or cleared tests are limited. These have several implications including a high-cost and long turnaround time (TAT) (Ascencio-Carbajal et al, 2021;Entidad Mexicana de Acreditación AC;Valdespino Gómez & Balbín Felechosa, 2016). The establishment of childhood risk-factors and their validation in large scale population studies, family-based sequencing, the discussion of variants in multidisciplinary groups of experts and the evaluation of risk factors in prenatal, pregnancy and postnatal period, will improve the knowledge of the genetic basis and the origin of childhood tumors.…”

“…Second, there are few laboratories that meet the international regulations of institutions such as The College of American Pathologist, CAP or The American College of Medical Genetics and Genomics, ACMG, and third, the number of available FDA approved or cleared tests are limited. These have several implications including a high‐cost and long turnaround time (TAT) (Ascencio‐Carbajal et al., 2021; Entidad Mexicana de Acreditación AC; Valdespino Gómez & Balbín Felechosa, 2016).…”