Around the year 1550, an indigenous tlacuilo (painter-scribe-historian) in Tepechpan, a small altepetl north of Mexico City, narrated the tumultuous events through which he had lived. In Figure 1, we see an excerpt of this tlacuilo's contribution to the town's annals, the Tira de Tepechpan, which depicts a sequence of events from 1545 to 1549. On the left, beneath the glyph for the year 1545, the tlacuilo paints a dangling corpse, its arms crossed and eyes shut, with blood spurting from the nose and mouth. Here the tlacuilo is telling us of the 1545 hueycocolixtli, the “great sickness” that killed at least a third of the population, according to conservative estimates. Among the victims was Tepechpan's ruler, the crowned figure wrapped in funeral cloth above the year glyph.