El cáncer de mama en el siglo XXI: de la detección precoz a los nuevos tratamientos

Bonilla, Jose; Tabanera, M. Torres; Mendoza, L.H. Ros

doi:10.1016/j.rx.2017.06.003

Cited by 88 publications

(24 citation statements)

References 66 publications

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“…Breast cancer (BC) is a heterogeneous disease associated with a variety of morphological, molecular features, outcomes and response to therapy [1]. Although BC outcome has improved over the years, 20-30% of patients develop distant metastasis with subsequent poor outcome [2].…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer

Kariri

Joseph

Kurozumi

et al. 2019

Breast Cancer Res Treat

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Background KN motif and ankyrin repeat domains 1 (KANK1) plays an important role in cytoskeleton maintenance and contributes to the regulation of cell proliferation, adhesion and apoptosis. KANK1 is involved in progression of a variety of solid tumours; however, its role in invasive breast cancer (BC) remains unknown. This study aims to evaluate the clinicopathological and prognostic value of KANK1 expression in operable BC. Methods KANK1 expression was assessed at the transcriptomic level using multiple BC cohorts; the Molecular Taxonomy of BC International Consortium cohort (METABRIC; n = 1980), The Cancer Genome Atlas BC cohort (TCGA; n = 949) and the publicly available BC transcriptomic data hosted by BC Gene-Expression Miner (bc-GenExMiner v4.0) and Kaplan-Meier plotter?. The Nottingham BC cohort (n = 1500) prepared as tissue microarrays was used to assess KANK1 protein expression using immunohistochemistry (IHC). The association between clinicopathological variables and patient outcome was investigated. Results In the METABRIC cohort, high expression of KANK1 mRNA was associated with characteristics of good prognosis including lower grade, absence of lymphovascular invasion and HER2 negativity (all; p < 0.001) and with better outcome [p = 0.006, Hazards ratio, (HR) 0.70, 95% CI 0.54-0.91]. High KANK1 protein expression was correlated with smaller tumour size and HER2 negativity, and better outcome in terms of longer breast cancer-specific survival [p = 0.013, HR 0.7, 95% CI 0.536-0.893] and time to distant metastasis [p = 0.033, HR 0.65, 95% CI 0.51-0.819]. Conclusion These results supported that upregulation of KANK1 works as a tumour suppressor gene in BC and is associated with improved patients' outcomes.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer

Kariri

Joseph

Kurozumi

et al. 2019

Breast Cancer Res Treat

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“…Breast cancer incidence rises sharply nowadays and has become the second most dangerous cancer among women although the great advantages have been made in diagnosis and treatments [14] . Up to date, miRNAs have been proved as master regulators of the tumor progression highlighted in various malignancies including breast cancer [15,16] .…”

Section: Discussionmentioning

confidence: 99%

miR-105-3p acts an oncogene to promote proliferation and metastasis of breast cancer cell by targeting GOLIM4miR-105-3p acts an oncogene to promote proliferation and metastasis of breast cancer cell by targeting GOLIM4

Lin

Shi

Qiu

et al. 2020

Preprint

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Background: Dysregulation of miRNAs is involved in carcinogenesis of breast cancer and may be used to prognostic biomarkers and therapeutic target during cancer process. The purpose of this study was to explore the effects of miR-105-3p on tumourigenicity of breast cancer and its underlying molecular mechanisms.Methods: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was applied to detect the miR-105-3p in breast cancer tissues. The impacts of miR-105-3p on proliferation, migration, invasion and apoptosis of human breast cancer lines (MCF-7 and ZR-75-30) were evaluated by CCK-8, transwell chamber assay, TUNEL assay and western blot assay, respectively. Besides, bioinformatics and luciferase reporter assay were used find out the targeted gene of miR-105-3p.Results: The expression of miR-105-3p was elevated in breast cancer tissues and increased with tumor severity. Downregulation of miR-105-3p could inhibit cell proliferation, suppress cell migration/invasion, and promote cell apoptosis in MCF-7 and ZR-75-30 cells. Furthermore, Golgi integral membrane protein 4 (GOLIM4) was identified to be the direct target gene of miR-105-3p by bioinformatics and luciferase reporter assay. In addition, silencing of GOLIM4 could restore the anti-breast cancer effects induced by miR-105-3p downregulation.Conclusions: miR-105-3p acts an oncogene to promote proliferation and metastasis of breast cancer cell by targeting GOLIM4, which provides a new target for the prevention and treatment of breast cancer.

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“…Currently, due to the negligence of women regarding the self-inspection and clinical examination of the breast, early detection of breast cancer remains difficult [3,4]. In patients who have been identified with breast tumor, different strategies of management are used such as hormonal therapy, radiation therapy, surgery and chemotherapy [4][5][6][7][8]. In individuals with distant metastasis, managements are typically aimed at enhancing life quality and survival rate [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese biomedical preparation (Huaier Granule) for breast cancer: a PRISMA-compliant meta-analysis

Yao

et al. 2020

Bioscience Reports

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Huaier Granule, a type of traditional Chinese biomedical preparation (TCBP), is considered to be a promising adjuvant therapy for breast cancer. Although an analysis of the published literature has been performed, the exact effects and safety of Huaier Granule remains controversial. Therefore, a wide-ranging systematic search of electronic databases from which to draw conclusions was performed. Data from 27 trials, including 2,562 patients with breast cancer were analyzed. The results indicated that, compared with conventional treatment alone, the combination of conventional treatment and Huaier Granule markedly improved patients’ overall response (P = 0.02) and quality of life (P < 0.00001), and significantly prolonged 2-year (P = 0.02), 3-year (P < 0.0001) and 5-year (P = 0.004) overall survival rates, and 1-year (P = 0.003), 2-year (P < 0.00001), 3-year (P < 0.00001) and 5-year (P = 0.03) disease-free survival. The immune function of patients was also significantly enhanced after combined intervention treatment, indicated by clearly increased percentages of CD3+ (P = 0.05), CD4+ (P < 0.00001) and natural killer cells (P < 0.0001), and CD4+/CD8+ ratio (P < 0.00001). The incidence of myelosuppression (P = 0.001), and hepatotoxicity (P = 0.05) was lower in breast cancer patients treated with Huaier Granule, whereas other adverse events did not differ significantly between the two groups (P>0.05). In summary, results of this meta-analysis suggest that the combination of conventional treatment and Huaier Granule is more effective for the treatment of breast cancer than conventional treatment alone.

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El cáncer de mama en el siglo XXI: de la detección precoz a los nuevos tratamientos

Cited by 88 publications

References 66 publications

Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer

Prognostic significance of KN motif and ankyrin repeat domains 1 (KANK1) in invasive breast cancer

miR-105-3p acts an oncogene to promote proliferation and metastasis of breast cancer cell by targeting GOLIM4miR-105-3p acts an oncogene to promote proliferation and metastasis of breast cancer cell by targeting GOLIM4

Traditional Chinese biomedical preparation (Huaier Granule) for breast cancer: a PRISMA-compliant meta-analysis

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