El cáncer colorrectal en la poliposis adenomatosa familiar: ¿existen factores clínicos de predicción?

Campos, Fábio Guilherme; Freitas, Isabella; Imperiale, Antônio Rocco; Seid, Víctor Edmond; Perez, Rodrigo Oliva; Nahas, Sérgio Carlos; Cecconello, Ivan

doi:10.1016/j.ciresp.2010.05.013

Cited by 4 publications

(1 citation statement)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, family studies have been done which indicate that this family risk is the result of a partial hereditary susceptibility [ 17 ]; c) the hereditary type, with two tumour variants which can be distinguished by the predisposition to being related to the presence of adenomatous polyps or not. We can distinguish: 1) familial adenomatous polyposis or FAP using its initials in English, in which the patients present with multiple polyps, which in the absence of preventive surgery, one or more may become malignant at the average age of 40 [ 18 ]; 2) the variant not associated with polyposis, or HNPCC (hereditary nonpolyposis colorectal cancer) by its initials in English, which is a malignant tumour with a high risk for developing a non-digestive cancer [ 19 ]. In the case of the sporadic type, this includes the majority of CRC cases, representing 60–80% of them, and is characterised by the fact that it does not show any type of family relationship.…”

Section: Classification Of Colorectal Cancermentioning

confidence: 99%

Biology of colorectal cancer

Arvelo¹,

Sojo²,

Cotte

2015

ecancer

108

View full text Add to dashboard Cite

Colorectal cancer is a serious health problem, a challenge for research, and a model for studying the molecular mechanisms involved in its development. According to its incidence, this pathology manifests itself in three forms: family, hereditary, and most commonly sporadic, apparently not associated with any hereditary or familial factor. For the types having inheritance patterns and a family predisposition, the tumours develop through defined stages ranging from adenomatous lesions to the manifestation of a malignant tumour. It has been established that environmental and hereditary factors contribute to the development of colorectal cancer, as indicated by the accumulation of mutations in oncogenes, genes which suppress and repair DNA, signaling the existence of various pathways through which the appearance of tumours may occur. In the case of the suppressive and mutating tracks, these are characterised by genetic disorders related to the phenotypical changes of the morphological progression sequence in the adenoma/carcinoma. Moreover, alternate pathways through mutation in BRAF and KRAS genes are associated with the progression of polyps to cancer. This review surveys the research done at the cellular and molecular level aimed at finding specific alternative therapeutic targets for fighting colorectal cancer.

show abstract

Section: Classification Of Colorectal Cancermentioning

confidence: 99%