The field of computational fluid dynamics has been rekindled by recent researchers to unleash this powerful tool to predict the ejector design, as well as to analyse and improve its performance. In this paper, CFD simulation was conducted to model a 2-D axisymmetric supersonic ejector using NIST real gas model integrated in ANSYS Fluent to probe the physical insight and consistent with accurate solutions. HFOs (1234ze(E) and 1234yf) were used as working fluids for their promising alternatives, low global warming potential (GWP), and adhering to EU Council regulations. The impact of different operating conditions, performance maps, and the Pareto frontier performance approach were investigated. The expansion ratio of both refrigerants has been accomplished in linear relationship using their critical compression ratio within ±0.30% accuracy. The results show that R1234yf achieved reasonably better overall performance than R1234ze(E). Generally, by increasing the primary flow inlet saturation temperature and pressure, the entrainment ratio will be lower, and this allows for a higher critical operating back pressure. Moreover, it was found out that increasing the degree of superheat for inlet primary flow by 25 K improved the entrainment ratio by almost 20.70% for R1234yf. Conversely, increasing the degree of superheat to the inlet secondary flow has a relativity negative impact on the performance. The maximum overall ejector efficiency reached was 0.372 and 0.364 for R1234yf and R1234ze(E) respectively. Comparing the results using ideal gas model, the ejector entrainment ratio was overestimated up to 50.26% for R1234yf and 25.66% for R1234ze(E) higher than using real gas model. systems relying on fossil fuels and the use of harmful substances such as chlorofluorocarbons (CFCs) as refrigerants. In fact, the emissions from these systems also contribute to ozone depletion which is most likely to increase the demand for air-conditioning, especially for thermal comfort [2].Compared with conventional systems, ejector refrigeration systems (ERS) are more attractive, especially as we become more energy conscious. ERS come with advantages such as simple mode of function, lack of moving parts in construction, low cost, long lifespan, in addition to simplicity of installation and maintenance. This refrigeration system utilizes an ejector, generator and a liquid pump in place of the compressor which is electricity driven [3]. For a low-grade heat source, the liquid pump may consume up to 1% of the supplied heat to the ejector system. Compared to other conventional systems of the same refrigerating capacity, the ejector system may consume only one fifth of electricity consumed by the other systems [4,5].Coefficient of performance (COP) is one of the main parameters for measuring ejector efficiency. The cooling systems of the refrigeration system may be analyzed from the COP. There exists a healthy relationship between the COP and the entrainment ratio in ejector cooling systems such that systems with high COP have high entrainme...