Abstract:Introduction:In recent generation, the difficult task is to overcome solubility problems in the formulation development of the drug. The lower water solubility of drugs causes various challenges in developing formulations and the use of harmful organic solvents produces toxicity. So, this problem is overcome by the mixed solvency concept proposed by Dr R.K. Maheshwari in 2009. In this work, amlodipine besylate was chosen as a model drug and solubilizers selected were sodium benzoate, sodium acetate, sodium cit… Show more
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