Eiweißgehalt und kolloidosmotischer Druck im Serum von Fieberkranken

Oelkers, H. A.; Ohnesorge, G.

doi:10.1007/bf02622366

Cited by 9 publications

(3 citation statements)

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“…During convalescence, the ratio increased in most cases. In 2 cases, the ratio was less than 1 during convalescence, and in 4 cases it varied from 1.17 to 1.62. It appeared that increase in fibrinogen and globulin usually, but not always, paralleled a decrease in the sedimentation time of erythrocytes, as shown previously by others (18,19,20,21 (26) and others to occur 1 to 4 hours after non-specific protein injection. The simultaneous increase of fibrinogen, increase of leukocytes and decrease of platelets In lobar pneumonia point to a common site of disturbance, probably in the hematopoietic organs.…”

Section: Discussionsupporting

confidence: 78%

“…Other factors, including hydremia, anemia, changes in cell volume and color index, also influence the suspension stability (14,15,16,17). Possibly because of these other factors, a number of observers have been unable to establish a constant correlation between fractional protein changes and sedimentation time (18,19,20,21). In two reports (19,21) the changes in the amount of fibrinogen, which is known to play the most important role in suspension stability, were not measured.…”

mentioning

confidence: 99%

“…Possibly because of these other factors, a number of observers have been unable to establish a constant correlation between fractional protein changes and sedimentation time (18,19,20,21). In two reports (19,21) the changes in the amount of fibrinogen, which is known to play the most important role in suspension stability, were not measured. The studies reported in this paper were undertaken to determine the correlation between fractional plasma protein changes, plasma viscosity and the sedimentation time of erythrocytes during and after lobar pneumonia.…”

mentioning

confidence: 99%

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Plasma Protein Changes and Suspension Stability of the Blood in Lobar Pneumonia

Moen

Reimann²

1933

J. Clin. Invest.

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Numerous studies have been made on the relation of fractional blood protein changes to bacterial infection and immunity. The subject is of especial importance in view of the renewed interest regarding the association of immune bodies with the globulins and recent studies in regard to the effects of blood protein changes and plasma viscosity on specific and non-specific agglutination reactions (1, 2). Since the early experiments of Langstein and Mayer (3), it has been generally found that a relative or absolute increase of the globulin fraction and a decrease in the albumin fraction occur during and after various bacterial infections. Glaessner (4) and later Hurwitz and his co-workers (5) showed that increases in globulin may occur during the course of immunization as well. They believed that the globulin increase indicated disturbed metabolism and that no direct parallelism existed between the amount of globulin and the degree of immunity. There was no constant relationship between the increased amount of globulin and the antitoxic potency of prepared sera. Similar findings were noted by Schmidt and Tuljtschinskaja (6) and others. Studies on fractional blood protein changes in malaria, typhoid fever and after typhoid vaccination were made by Lloyd and Paul (7). They observed a marked decrease in the albumin fraction, an increase in the euglobulin and slight or no changes in the total globulin during the acute stage of typhoid fever and malaria. Similar but less marked changes followed vaccination with typhoid bacilli.Many studies have been made on the blood protein changes in lobar pneumonia. Kumpf (8) collected data from 29 reports. It was generally agreed that the total protein was lowered, the fibrinogen and globulin increased and the albumin decreased in amount. No particular attention, however, was given to the speed with which changes in plasma proteins occur after the onset of infection or the time required before the normal equilibrium was regained.Increase of plasma globulin and fibrinogen during infections causes a decrease of the suspension stability of the blood and consequent reduction of the sedimentation time of erythrocytes. The correlation between plasma protein changes and sedimentation time has been demonstrated 589

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Section: Discussionsupporting

confidence: 78%