Eisenmenger syndrome and idiopathic pulmonary arterial hypertension: do parenchymal lung changes reflect aetiology?

Griffin, Nyree; Allen, Darlene; Wort, John; Rubens, Michael B.; Padley, Simon

doi:10.1016/j.crad.2007.01.013

Cited by 20 publications

(11 citation statements)

References 17 publications

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“…On the basis of our experience, including 87 patients with PAH-CHD (compared with 24 in Sheehan's study and 20 in Griffin's) and 111 patients with IPAH (compared with 14 of Sheehan's and 8 of Griffin's) we are able to substantially confirm the results obtained by Griffin and coworkers [5]: neovascularity was present in 72% of PAH-CHD and in 22% of IPAH (versus 21% in Sheehan's study and 25% in Griffin's) with a statistically significant difference. Instead the incidence of patients with neovascularity in the study by Sheehan was 96%.…”

Section: Discussionsupporting

confidence: 86%

“…There are few studies in the literature on neovascularity, including that of Sheehan [4] and Griffin and coworkers [5].…”

Section: Discussionmentioning

confidence: 99%

“…Among the cardiac, vascular and pulmonary abnormalities that can be found in patients with PAH, the neovascularity is a less well-known CT lung finding that has been recently discovered; despite its relatively high incidence, we have found only a few works published in the scientific literature about it [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients

Modolon¹,

Attinà²,

Buia³

et al. 2011

Eur Radiol

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• Large retrospective studying specific lung disorders in patients with pulmonary arterial hypertension. • Neovascularity is often the first CT sign indicating the severity of pulmonary hypertension Alterations of lung parenchyma on CT in pulmonary hypertension are described • The first study to assess the severity of pulmonary hypertension by CT • If substantiated, CT might eventually replace some cardiac catheterisation for evaluating PH.

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Section: Discussionsupporting

confidence: 86%

“…There are few studies in the literature on neovascularity, including that of Sheehan [4] and Griffin and coworkers [5].…”

Section: Discussionmentioning

confidence: 99%

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Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients

Modolon¹,

Attinà²,

Buia³

et al. 2011

Eur Radiol

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“…2c) [28]. Centrilobular opacities are, however, a nonspecific finding in PAH and can be seen with idiopathic and other forms of PAH [29].…”

Section: Evaluation Of the Lung Parenchymamentioning

confidence: 99%

Cardiac causes of pulmonary arterial hypertension: assessment with multidetector CT

et al. 2009

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The causes of pulmonary arterial hypertension (PAH) are diverse and include multiple congenital and acquired cardiac diseases as well as diseases primarily affecting the pulmonary vasculature, lung, pleura and chest wall. The traditional role of CT in evaluating PAH includes assessment of pulmonary vasculature and lung parenchyma with limited assessment of the heart. Advances in multidetector CT technology with improved spatial and temporal resolution now permit accurate delineation of cardiac morphology. CT pulmonary angiography (CTPA) is widely utilised in the workup of patients with suspected pulmonary vascular disease and can identify both pulmonary and cardiac causes. As the initial presentation for CTPA is often precipitated by nonspecific, unexplained symptoms and therefore undertaken by a general radiologist, it is important that a systematic approach to the interpretation of these studies, including cardiac evaluation, is routinely adopted. This paper reviews the CT evaluation in pulmonary hypertension with a particular focus on the cardiac causes, their subclassification into congenital systemic to pulmonary shunts and secondary to left heart disease, and their imaging features. It emphasises the use of a systematic approach to interpretation of CTPA examinations both in patients with known PAH and those with previously unsuspected disease.

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“…Eisenmenger syndrome (ES) shares many aspects of the clinical and hemodynamic alterations as well as pulmonary microvascular changes with other forms of pulmonary arterial hypertension (PAH) 1,2 . However, ES patients seem to have a better prognosis compared especially with those with idiopathic PAH 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated With Mortality in Eisenmenger Syndrome

Jensen

Broberg

Rydman

et al. 2015

Circ: Cardiovascular Imaging

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Eisenmenger syndrome and idiopathic pulmonary arterial hypertension: do parenchymal lung changes reflect aetiology?

Cited by 20 publications

References 17 publications

Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients

Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients

Cardiac causes of pulmonary arterial hypertension: assessment with multidetector CT

Impaired Right, Left, or Biventricular Function and Resting Oxygen Saturation Are Associated With Mortality in Eisenmenger Syndrome

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