Eisenmangel, Thrombozytose und Thromboembolie

Evstatiev, Rayko

doi:10.1007/s10354-016-0514-6

Cited by 17 publications

(6 citation statements)

References 128 publications

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“…Iron deficiency is an underestimated thromboembolic risk factor. Although the secondary thrombocytosis that occurs with IDA is usually considered to be harmless, there is accumulating evidence that elevated platelet counts, especially in the setting of iron deficiency, can lead to an increased thromboembolic risk in both arterial and venous systems [1]. In this regard, several studies have reported various VTE events attributable to IDA.…”

Section: Discussionmentioning

confidence: 99%

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Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis

Ezeh¹,

Katabi²,

Khawaja³

2021

Cureus

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Iron deficiency is a well-known cause of anemia. However, it is an under-recognized cause of venous thromboembolism (VTE). Iron deficiency predisposes to VTE mainly by inducing thrombocytosis, which can lead to a hypercoagulable state. Identifying iron deficiency as a possible cause of thromboembolic phenomena has clinical significance since this is a potentially avoidable risk factor. This case report serves as a reminder that iron deficiency is an important risk factor for VTE that should be considered in the evaluation of patients. This is particularly true in patients like ours who have recurrent venous thromboembolic disease.

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Section: Discussionmentioning

confidence: 99%

“…Iron deficiency, the most common nutritional deficiency worldwide, is often associated with reactive thrombocytosis, which can cause a hypercoagulable state [1]. The hypercoagulable state is one of the components of Virchow's triad, which explains the possibility of increasing risk of venous thromboembolism (VTE) associated with it.…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis

Ezeh¹,

Katabi²,

Khawaja³

2021

Cureus

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“…The rate of thrombocytosis in patients with iron deficiency anemia was reported to be as high as 33% [ 4 ], with a strong negative correlation with the severity of anemia [ 5 , 6 ]. Untreated iron deficiency anemia, which causes elevated levels of erythropoietin, is postulated to cause increased platelets in addition to red blood cells (RBCs) due to the proliferation of common progenitor cells in the bone marrow [ 7 ]. A similar sequence of amino acids between erythropoietin and thrombopoietin, the predecessors of red blood cells and platelets, respectively, has been proposed as a potential mechanism by which elevated erythropoietin may lead to thrombocytosis [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Reactive Thrombocytosis Related Cerebral Venous Thrombosis: A Rare Complication of Untreated Iron Deficiency Anemia

Maryala¹,

Vaddiparti²

2021

Cureus

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Thrombocytosis can be either primary or secondary, and it can cause venous pro-thrombotic states like cerebral venous thrombosis. Untreated iron deficiency anemia is postulated to cause reactive (secondary) thrombocytosis due to the proliferation of common progenitor cells. Here we present a case of a middleaged woman with polycystic ovary syndrome and episodes of menorrhagia. She presented with headache and focal sensory deficits, and her neuroimaging showed evidence of cerebral venous sinus thrombosis (CVST). Laboratory tests showed microcytic hypochromic anemia, low ferritin, high total iron-binding capacity (TIBC), and thrombocytosis with a platelet count of 1,523,000/mm³. A comprehensive workup for hypercoagulable states and primary causes of thrombocytosis was negative. It was concluded that the etiology of her CVST was a reactive thrombocytosis from chronic untreated iron deficiency anemia. Anticoagulation with apixaban and corrective treatment for iron deficiency anemia was initiated. A repeated neuroimaging after four months showed significantly less clot burden in the cerebral venous sinuses, and then apixaban was stopped after six months. Laboratory tests after one year of iron replacement therapy showed improvement in the hemoglobin and hematocrit as well as normalization of platelet count. This case highlights a rare yet potentially dangerous complication of a common untreated condition, i.e., iron deficiency anemia.

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“…Iron-deficiency anemia (IDA), the primary cause of non-hemorrhagic anemia in young females—especially non-pregnant women—has been proposed to increase thromboembolic events. Some authors have concluded that transferrin overexpression due to IDA might enhance the thrombosis potential by inactivating antithrombin through the thrombin/Factor XIIa complex [ 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Anemia and Stroke in Females: A Nationwide, Population-Based Cohort Study in Taiwan

Yuan

Hong

Chien

et al. 2020

IJERPH

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Optimal stroke prevention strategies for women should take into account specific sex-related stroke risk factors. Anemia is a common medical condition in females, particularly in women of reproductive age. This study investigated whether anemia is an independent risk factor for stroke in females in a population-based cohort study. We investigated newly diagnosed anemic female patients with no history of central nervous system disease, psychiatric disorders, traumatic brain injury, major operations or hemorrhagic diseases identified from the Taiwan National Health Insurance Research Database. Non-anemic matched controls (1:1) were selected based on a propensity score estimated using a logistic regression model that included demographic characteristics and comorbidities. A competing risk analysis was applied to estimate the stroke risk in anemic patients compared to that of their matched controls. In our study, the adjusted sub-distribution hazard ratios (aSHRs) of overall, hemorrhagic and ischemic stroke in anemic female patients aged <50 years were 1.35 (95% confidence interval (CI): 1.19–1.52, p < 0.001), 1.31 (95% CI, 1.09-1.56, p < 0.003), and 1.35 (95% CI, 1.15–1.58, p < 0.001), respectively, compared to non-anemic female controls. However, a positive association between anemia and stroke was not found for those aged ≥50 years. Similar results were observed when the follow-up age was limited to 50 years to reduce the potential effects of menopause on stroke. In conclusion, the present population-based cohort study found that anemia is a potential risk factor for overall, hemorrhagic and ischemic stroke in females of reproductive age.

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Eisenmangel, Thrombozytose und Thromboembolie

Cited by 17 publications

References 128 publications

Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis

Iron Deficiency Anemia as a Rare Risk Factor for Recurrent Pulmonary Embolism and Deep Vein Thrombosis

Reactive Thrombocytosis Related Cerebral Venous Thrombosis: A Rare Complication of Untreated Iron Deficiency Anemia

Association between Anemia and Stroke in Females: A Nationwide, Population-Based Cohort Study in Taiwan

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