Einleitung

Kemper, Dirk

doi:10.30965/9783846755785_003

Cited by 1 publication

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“…Identification and determination of MRB in its raw material using HPLC‐IR detectors was recommended as the official pharmacopeial analysis protocol [9]. Other chromatographic techniques for quantification of MRB residues in the biological, aquatic and terrestrial environment were also reported [11–16].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Marbofloxacin at Carbon Paste Sensor Integrated with Copper Oxide Nanoparticles

2022

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The present work introduced copper oxide nanoparticles as an efficient electrode modifier for sensitive adsorptive differential pulse voltammetric assaying of marbofloxacin (MRB) in pharmaceutical formulations and surface water samples. In the presence of sodium dodecyl sulphate (SDS) at pH 4.0, the marbofloxacin molecule was irreversibly oxidized at the electrode surface showing an anodic oxidation peak at 0.954 V. The electrode reaction mechanism was assumed as adsorption‐reaction controlled accompanied by the transferring of two electrons and proton exchange in agreement with the molecular orbital calculations performed on MRB molecule suggesting the oxidation of the amino group in the piperazinyl ring. At the optimized measuring conditions, the recorded peak heights were linearly correlated with the MRB concentration within the range from 6.67 to 360 ng mL−1, and the estimated LOD value was 2.2 ng mL−1. The integrated sensor showed a prolonged operational lifetime with good reproducibility of measurements. Based on the selectivity and sensitivity of the proposed method, MRB was successfully assayed in pharmaceutical formulations and surface water samples with mean average recoveries agreeable with the official method.

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Section: Introductionmentioning

confidence: 99%