Einfluss von 20 % Schwefelhexafluorid (SF6) auf humane korneale Endothelzellen

Schaub, Friederike; Simons, Hans G.; Roters, Sigrid; Heindl, Ludwig M.; Kugler, Walter; Bachmann, Björn; Cursiefen, Claus

doi:10.1007/s00347-015-0051-5

Cited by 27 publications

(1 citation statement)

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“…Although the gas is thought to be inert, increased buoyancy and longevity of the gas may have mechanical effects on the endothelial surface (13) . A recent in vitro study, however, found no significant difference between SF 6 and air on endothelial cell counts or toxicity of corneal endothelial cells (14) . Additionally, Guell et al found no difference in endothelial cell counts between use of SF 6 or air ≤3years after DMEK (9) .…”

Section: Discussionmentioning

confidence: 82%

Comparison of 20% sulfur hexafluoride with air for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK)

Botsford¹,

Vedana²,

Cope³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To compare the effect of 20% sulfur hexafluoride (SF 6 ) with that of air on graft detachment rates for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK). Methods: Forty-two eyes of patients who underwent DMEK by a single surgeon (A.S.J.) at Wilmer Eye Institute between January 2012 and 2014 were identified; 21 received air for intraocular tamponade and the next consecutive 21 received SF 6 . The main outcome measure was the graft detachment rate; univariate and multivariate analyses were performed. Results: The graft detachment rate was 67% in the air group and 19% in the SF 6 group (p<0.05). No complete graft detachments occurred, and all partial detachments underwent intervention with injection of intraocular air. The percentages of eyes with 20/25 or better vision were not different between the groups (67% vs. 71%). Univariate analysis showed significantly higher detachment rates with air tamponade (OR, 8.50; p<0.005) and larger donor graft size (OR, 14.96; p<0.05). Multivariate analysis with gas but not graft size included showed that gas was an independent statistically significant predictor of outcome (OR, 6.65; p<0.05). When graft size was included as a covariate, gas was no longer a statistically significant predictor of detachment but maintained OR of 7.81 (p=0.063) similar to the results of univariate and multivariate analyses without graft size. Conclusion:In comparison with air, graft detachment rates for intraocular tamponade in DMEK were significantly reduced by 20% SF 6 .

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