Einfluss der Untersuchererfahrung auf intra- und interindividuelle Variabilität bei der Erfassung der peripheren Endothelfunktion mittels hochauflösendem Ultraschall

Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and its effect on inflammatory markers in non-diabetic men. Forty non-obese, healthy men with normal glucose tolerance were randomised to a single dose of rosiglitazone (8 mg) or placebo, and FMD was assessed at baseline as well as after 6 h and 24 h. Rosiglitazone did not significantly affect blood glucose and insulin levels or lipid parameters after 6 and 24 h compared with placebo. Treatment with rosiglitazone significantly increased FMD after 6 h from 4.3% (3.3; 4.9) to 7.6% (5.6; 9.2) (p<0.0001 vs. baseline) resulting in a highly significant effect compared with placebo (p<0.0001 for difference between groups). After 24 h FMD was still significantly higher in the rosiglitazone group compared with baseline (p=0.001), but the effect was no longer statistically significant versus placebo (p=0.171). Our study shows a very rapid effect of single dose rosiglitazone treatment on endothelial function in non-diabetic healthy men, underscoring the hypothesis that TZDs may exhibit direct effect in the vasculature independent of their metabolic action.

show abstract

“…Standard FMD [14][15][16] was assessed as follows. All subjects were studied at rest in supine position.…”

Section: Endothelial Function Testingmentioning

confidence: 99%

Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study

Walcher

Hetzel

et al. 2010

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

show abstract

“…Standard flow-mediated, endothelium-dependent vasodilation [17][18][19] was assessed as follows. All subjects were studied at rest in supine position.…”

Section: Endothelial Function Testingmentioning

confidence: 99%

Rapid Effects of Rosiglitazone Treatment on Endothelial Function and Inflammatory Biomarkers

Hetzel

Balletshofer

Rittig

et al. 2005

ATVB

133

View full text Add to dashboard Cite

Background— Antidiabetic thiazolidinediones (TZDs), like rosiglitazone or pioglitazone, improve endothelial function in patients with type 2 diabetes or metabolic syndrome, but it is currently unknown, whether these beneficial effects of TZDs depend on their metabolic action or may be caused by direct effects on the endothelium. Therefore, the present study examined whether short-term rosiglitazone treatment influences endothelium-dependent vasodilation as well as serum levels of vascular disease biomarkers in healthy, nondiabetic subjects. Methods and Results— Short-term treatment (21 days) of healthy subjects (n=10) did not significantly change blood glucose levels or lipid profile. In contrast, rosiglitazone significantly increased flow-mediated, endothelium-dependent vasodilation already within the first day from 5.3±2.7% at baseline to 7.8±2.6%, further increasing it to 9.4±3.0% at day 21. In addition, the early improvement of endothelium-dependent vasodilation was paralleled by a rapid reduction of serum levels of the biomarkers C-reactive protein (CRP), serum amyloid A (SAA), and sE-selectin. Moreover, after drug withdrawal all markers remained suppressed for the whole follow-up period of 7 days. In contrast, rosiglitazone treatment did not significantly affect tumor necrosis factor (TNF)-α, interleukin (IL)-6, sICAM-1, sVCAM-1, and sCD40L levels. Conclusions— Our study suggests a direct effect of TZD treatment on endothelial function and inflammatory biomarkers of arteriosclerosis, promoting the concept that TZDs, independent of their metabolic action, may exhibit protective effects in the vessel wall.

show abstract

Impairment of shear-stress-mediated vasodilation of cavernous arteries in erectile dysfunction

Virag¹,

Floresco²,

Richard³

2004

Int J Impot Res

View full text Add to dashboard Cite

Penile NO release test (PNORT) has been designed to try to evaluate clinically the penile endothelial function (PEF). The shear-stress flow-mediated vasodilation (FMD) of the cavernous arteries is evaluated in two groups of patients with neurogenic (n¼23) and vasculogenic (n¼23) erectile dysfunction (ED) by measuring their percent of increase after a 5 min occlusion of the flow. Both groups show an important FMD decrease (17.78711.78 and 17.82713%) as compared to the agematched control group (n¼12) (65.14730.5%, Po0.001). In the vasculogenic and control groups, mean FMD is lower in patients with one or more arterial risk factors(41 vs 67%, P¼0.025), and show a positive correlation with the plasmatic levels of bioavailable testosterone (r¼0.37, P¼0.03) and of DHEA-S (r¼0.46, P¼0.014). Patients achieving full erection at pharmacological test with visual sexual stimulation have a higher FMD (43.8738%) than those who did not (18.52714.37%, P¼0.008). We confirm clinically that PEF is strongly impaired in organic ED linked to neurological, vascular and endocrine factors.

show abstract

Einfluss der Untersuchererfahrung auf intra- und interindividuelle Variabilität bei der Erfassung der peripheren Endothelfunktion mittels hochauflösendem Ultraschall

Abstract: 30 training measurements of FAD under supervision should be regarded as minimum requirement for valid determination of endothelial function. The reachable result for the intra-observer variability is thereby within the range of computed analysis systems.

Cited by 6 publications

References 9 publications

Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study

Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study

Rapid Effects of Rosiglitazone Treatment on Endothelial Function and Inflammatory Biomarkers

Impairment of shear-stress-mediated vasodilation of cavernous arteries in erectile dysfunction

Contact Info

Product

Resources

About