Einflu� der Kultivation in vitro auf das Enzymmuster intrakranieller Tumoren

Matakas, F.

doi:10.1007/bf00242383

Cited by 9 publications

(1 citation statement)

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“…In view of the obvious difficulty in obtaining tissue samples and measuring drug concentrations in the human brain, the present studies were undertaken to discover the extent of penetration of three /adrenoceptor antagonists, propranolol, pindolol and atenolol, into cerebrospinal fluid (CSF), a more accessible compartment in the central nervous system (CNS). Furthermore, if, as has been suggested, there is free movement of molecules between CSF and brain extracellular water (Matsen & West, 1972;Matakas, Stechele & Keller, 1978), then knowledge of drug concentration in CSF rather than in brain 0306-5251/81/100549-11 $01.00 tissue may be more important when considering drug action. It is believed by some that 8-adrenoceptors are situated on the surface of cells.…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid concentrations of propranolol, pindolol and atenolol in man: evidence for central actions of beta‐adrenoceptor antagonists.

Taylor¹,

Jefferson²,

Carroll³

et al. 1981

Brit J Clinical Pharma

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1 Single and multiple oral dose studies of the penetration into CSF of three beta‐adrenoceptor antagonists were performed in groups of patients needing lumbar puncture as part of their neurological investigation. Propranolol, pindolol and atenolol were chosen because of their differing physico‐chemical properties. 2 The CSF concentration of propranolol (lipid‐soluble) and pindolol (moderately lipid‐soluble) was proportional to the free plasma concentration and was similar to, although generally lower than, that theoretically predicted. 3 The CSF concentrations of the poorly lipid‐soluble atenolol were similar in different patients and were independent of plasma concentration. This may be due to the slow rate of diffusion of atenolol into CSF preventing the predicted concentrations being achieved.

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Section: Introductionmentioning

confidence: 99%