Eine schwere percutane Vergiftung mit Parathion (E 605�)

Prinz, Helge

doi:10.1007/bf00577785

Cited by 9 publications

(1 citation statement)

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“…They are designed to reactivate the acetylcholinesterase-organophosphorus complex (AChE-OP) and therefore constitute a causal therapy. Clinical experience, Offprint requests to: J. Willems, Heymans Institute, De Pintelaan 185, B-9000 Ghent, Belgium however, shows that oximes are not always very efficienl as reactivators and in reversing the intoxication syndrome (Erdmann 1968;Prinz 1969;Szajewski and Glinska, 13th International Congress of the European Association of P0i-son Control Centres, 1988). In a series of 35 patients, we observed AChE reactivation and concomitant clinical recovery in only eight cases (Willems 1981).…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Willems

Langenberg²,

Verstraete³

et al. 1992

Arch Toxicol

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Using pharmacokinetic data from healthy human volunteers in a bicompartmental pharmacokinetic model, a repeated dose scheme for pralidoxime methylsulphate (Contrathion) was developed producing plasma levels remaining above the assumed "therapeutic concentration" of 4 mg.l-1. Using the same data, it was found that a concentration of 4 mg.l-1 could also be obtained by a loading dose of 4.42 mg.kg-1 followed by a maintenance dose of 2.14 mg.kg-1.h-1. In order to study the pharmacokinetic behaviour of pralidoxime in poisoned patients, this continuous infusion scheme was then applied in nine cases of organophosphorus poisoning (agents: ethyl parathion, ethyl and methyl parathion, dimethoate and bromophos), and the pralidoxime plasma levels were determined. The mean plasma levels obtained in the various patients varied between 2.12 and 9 mg.l-1. Pharmacokinetic data were calculated, giving a total body clearance of 0.57 +/- 0.27 l.kg-1.h-1 (mean +/- SD), an elimination half-life of 3.44 +/- 0.90 h, and a volume of distribution of 2.77 +/- 1.45 l.kg-1.

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Section: Introductionmentioning

confidence: 99%