Eine neue Möglichkeit zur Erfassung und Erklärung von Stoffwechselbesonderheiten bei hypertonen Typ-2-Diabetikern

Differences in electrolyte mismanagement between normotonic and hypertonic Type 2 diabetics detectable by correlative capillary blood evaluation

“…It turned out that high blood glucose alone already increases electrolyte metabolism, shown by positive correlations with Mg and glucose and negative correlations between Mg and pH which culminates in the highest Mg values along with highest glueose and lowest pH values in patients with eombined hyperglyeemia and hypertonia. Although we partly drew similar conclusions in a fonner paper [14], the step forward in the present work is that results won by eomparison of parameter changing (delta values) between two sampling events can be confirmed by using the directly determined data of just a single sample. Thus, appropriately processed data and eomparatively simple mathematical operations like implementation of linear regressions do not only detect significant differenees hidden behind similar group averages, but also con-siderably curtail the necessary diagnostie blood sampling.…”

“…In a preceding paper [14], dealing partly with the same patient sample, we were able to show, that hypertonic Type 2 diabetic patients do differ from normotonic diabetics in some important features of electrolyte metabolism, i.e. the correlations of ionized blood magnesium and ionized potassium with blood glucose and partly also with pH values.…”

Metabolic changes and hypomagnesiemia

“…We could show in this paper, that at least base -excess diminishment, lactate decrease and a fall in blood glucose average -whose wide ranging correlation is shown in Figure 8 -is significant already in the group with Mg-H-H averages below 0.5 mM/l and above 0.45 mM/l. It remains undisputed that below Mg-H-tlevels of 0.45 mMJl severe metabolic changes are evident, which may even be markers for the outcome of liver surgery [6,8,17]. But we also have to accept that metabolic deterioration is already significant in some important cases above 0.45 mM/l and below 0.5 mM/l.…”

“…About 100 |j.l of capillary blood of 306, mainly male probands out of our data banks, aged between 22 and 79 years have been analyzed for ionized magnesium, ionized calcium pH, pC02, blood glucose and lactate before and after a tolerable ergometric workload of 80 watts and 8 minutes, using a CCX analyzer (NOVA Biomédical, Vienna, Austria) and CSA (Clinical Stress Assessment) software by PLK, Judendorf -Strassengel, Austria) [4,5,6]. The probands were subdivided into three groups according to their basal Mg-H-values: Group 1 consisted of probands with Mg++ concentrations of 0.45 mM/l and lower.…”

CSA – Clinical Stress Assessment

“…Indeed, a highly significant, but negative correlation between pH and Ionized K ensues, positioning the most pronounced K loss along with the highest metabolic turnover, characterized in this overcompensating situation by the highest pH and lowest K values. A combination of electrolyte-and metabolic parameters therefore are seemingly able to characterize typical group idiosyncrasies (overcompensation in this case) as well as the individual position of the participants within the group ( fig.7 In such an adrenergic state of expectation, a further correlation can be expected, namely a proportional behaviour of pH and ionized magnesium, because adrenaline increase changes of pH via the mechanism mentioned above and can also increase ionized Mg in blood (8,9). However, no significant correlation could be found.…”