Ein Tischrechnerprogramm für „Diehl Alphatronic“ zur Erfassung von Störungen des Calcium- und Phosphathaushaltes

Schmidt-Gayk, H.; Stengel, R; Haueisen, H.; Martiskainen, I.; Ritz, Eberhard

doi:10.1007/978-3-642-85450-7_513

Verhandlungen Der Deutschen Gesellschaft Für Innere Medizin

1975

DOI: 10.1007/978-3-642-85450-7_513

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Ein Tischrechnerprogramm für „Diehl Alphatronic“ zur Erfassung von Störungen des Calcium- und Phosphathaushaltes

H. Schmidt-Gayk¹,

R Stengel²,

H. Haueisen³

et al.

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1979

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“…Vitamin D deficiency was documented by the analysis of plasma for the concentration of 250HD, using a modified radioreceptor assay (8). Plasma levels of 250HD were below the low limit of detectability for the assay (0.5 ng/ml) after 6 weeks of this diet.…”

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Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy

Gray

Lester

1979

Science

201

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The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.

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confidence: 99%

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy

Gray

Lester

1979

Science

201

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Ein Tischrechnerprogramm für „Diehl Alphatronic“ zur Erfassung von Störungen des Calcium- und Phosphathaushaltes

Cited by 1 publication

References 0 publications

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy

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Ein Tischrechnerprogramm für „Diehl Alphatronic“ zur Erfassung von Störungen des Calcium- und Phosphathaushaltes

Cited by 1 publication

References 0 publications

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D 3 in Pregnancy

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D 3 in Pregnancy

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Product

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Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy

Evidence for Extra-Renal 1 α-Hydroxylation of 25-Hydroxyvitamin D ₃ in Pregnancy