Ein sakrokokzygeales Chordom mit maligner Spindelzellkomponente

Abstract

Malignant fibrous histiocytoma (MFH), arising in combination with a sacral chordoma in a 70-year-old men, is described. Intermediate spindle-shaped cells demonstrating keratin positivity, showed a gradual transition between the areas of conventional chordoma, and the spindle cell areas, lending credence to the theory of a multipotential neoplasm. We chose the descriptive term "chordoma with malignant spindle cell component" in the sense that high malignant sarcomatous components exists in conjunction with chordomas in the primary tumor and the local recurrence. A review of literature is undertaken chronicling the documented associations of chordoma and sarcoma, followed by a discussion of the various causes proposed to explain this phenomenon.

Metastasizing chordoma of the lumbar spine

“…The appearance of metastases depends mainly on the histological differentiation of the tumour, and should not be correlated to the duration of the clinical course. However, a histological judgement is difficult, since significant prognostic influences of the cellular structure have not been proved yet [23,24]. The histological differential diagnosis comprises mucinous adenocarcinoma, chondrosarcoma, chondroma, pleomorphic adenoma, and the myxopapillary ependymoma.…”

Intracranial metastasis from a sacrococcygeal chordoma

“…of metastasis depends mainly on the histological differentiation of the tumor and should not be correlated to the duration of the clinical course. 6,10,11,[18][19][20][21][22][23][24][25] It appears that the metastatic potential of chordoma is higher than originally believed. Metastasis may be present with the primary tumor at the time of the initial presentation or it may develop months or years later.…”