Ein objektorientierter Ansatz zur Modellierung des menschlichen Herz-Kreislauf-Systems  An Object-Oriented Approach to Modelling the Human Cardiovascular System

Brunberg, Anja; Autschbach, Rüdiger; Abel, Dirk

doi:10.1524/auto.2008.0726

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Die objektorientiert aufgebaute Modellbibliothek "HumanLib" wurde zum einfachen und flexiblen Modellieren und Simulieren von dynamischen Zusammenhängen im menschlichen Herz-Kreislauf-System entwickelt [1]. Damit eine geeignete Simulationsplattform für die Entwicklung und den Test geregelter Assist-Systeme (z.…”

Section: Introductionunclassified

Simulation physiologischer Regelkreise mit der objektorientierten Modellbibliothek “HumanLib”

Brunberg¹,

Spillner²,

Autschbach

et al. 2011

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Zusammenfassung Die “HumanLib” ist eine objektorientiert aufgebaute Modellbibliothek bestehend aus Komponenten des Herz-Kreislauf-Systems sowie körpereigenen Regelkreisen. Im Beitrag werden Aufbau und Modellierungsmethodik beschrieben. Anhand zweier Testszenarien werden Simulationsdaten mit Messdaten aus einem in vivo Versuch am Kalb sowie physiologischen Normalwerten verglichen.

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Section: Introductionunclassified

Simulation physiologischer Regelkreise mit der objektorientierten Modellbibliothek “HumanLib”

Brunberg¹,

Spillner²,

Autschbach

et al. 2011

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1,079

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“…With regard to the simulation of human physiology, in contrast to previously developed models such as [2,7,10], no separation or sole assessment of hydraulics and thermodynamics is made in independent submodels. The focus is on the interaction of pressure and temperature changes.…”

Section: Discussionmentioning

confidence: 99%

Individual Cooling and Compression System for Accelerated Swelling Reduction on Fractures

Paessler¹,

Fielitz²,

Rathmann³

et al.

EPiC Series in Health Sciences

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After a fracture injury a swelling of the skin soft tissue results which prevents an early operation. In order to shorten the waiting time until the decrease of the swelling, the metabolism-reducing effect of mild local hypothermia and the swelling-reducing effect of compression therapy should be used in a device anatomically adjusted to the patient. For the best possible treatment, a regulation of the cooling and compression parameters should be carried out by means of sensor technology in order to allow an adaptation to the individual patient.After a fracture injury a swelling of the skin soft tissue results which prevents an early operation. In order to shorten the waiting time until the decrease of the swelling, the metabolism-reducing effect of mild local hypothermia and the swelling-reducing effect of compression therapy should be used in a device anatomically adjusted to the patient. For the best possible treatment, a regulation of the cooling and compression parameters should be carried out by means of sensor technology in order to allow an adaptation to the individual patient.Based on medical studies, parameter areas relevant to patients could be determined. These were implemented in first functional models for a cooling system and a compression system. Anatomically adapted cooling and pressure chambers allow a good physical coupling of the system to humans. The first test results, considering the heat emission and the skin elasticity properties of the human body, show that both rapid cooling can be achieved in a range of between 17 and 20°C of skin temperature within 4 min, and that under a pressure effect of between 10 and 20 kPa in the pressure chambers a pressure on the human tissue can be produced up to 15 kPa. The cooling system based on Peltier elements is capable of transporting a heat flow up to 10 W. The quiet, maintenance-free Peltier elements also increase the patient's acceptance. In the pressure chambers, a temporally overlapping generation of pressure pulses can imitate the process of natural walking by the effect of muscle pumps and contribute to a technical lymphatic drainage. By detecting the inflammation area with the aid of netlike-arranged temperature sensors and measuring the internal pressure of the pressure chambers in the case of a swelling tissue, cooling can be carried out at a determined point and the occurrence of, for example, a compartment syndrome can be prevented by regulating the pressure.At present still ongoing, promising developments of models for the consideration of the temperature distribution and pressure differences in the cardiovascular system should enable a determination of optimized cooling and pressure curves adapted to the individual human. In this way, the best possible control circuits should be identified using medical expert knowledge.

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An Object-oriented Model of the Cardiovascular System with a Focus on Physiological Control Loops

2009

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Ein objektorientierter Ansatz zur Modellierung des menschlichen Herz-Kreislauf-Systems An Object-Oriented Approach to Modelling the Human Cardiovascular System

Cited by 6 publications

References 11 publications

Simulation physiologischer Regelkreise mit der objektorientierten Modellbibliothek “HumanLib”

Simulation physiologischer Regelkreise mit der objektorientierten Modellbibliothek “HumanLib”

Individual Cooling and Compression System for Accelerated Swelling Reduction on Fractures

An Object-oriented Model of the Cardiovascular System with a Focus on Physiological Control Loops

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