Ein neuer Weg zu Schlüsselbausteinen für die Synthese von 5,6‐DiHETE und Lipoxin A<sub>4</sub>

Gigou, Agnès; Lellouche, Jean‐Paul; Beaucourt, J. P.; Toupet, Loı̈c; Grée, René

doi:10.1002/ange.19891010633

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…In another recent communication [ 452 ] the Grées group reported a new stereoselective synthesis of the erythro and threo carbonates 263, which are key intermediates for the preparation of (5,6)-DIHETES and Lipoxin A 4 (polyhydroxylated metabolities of the arachidonic acid cascade with their potent biological properties). Starting from the butadiene-tricarbonyl-iron complex 262, which has been resolved, the multi-step procedure includes a key step of highly diastereoselective osmylation of double bonds vicinal to the organometallic complex (e.g., the dienyl-Fe(CO) 3 moiety).…”

Section: Synthesis Of Natural Products Via Iron Carbonylsmentioning

confidence: 99%

New chemical and stereochemical applications of organoiron complexes

Fatiadi

1991

J. RES. NATL. INST. STAN.

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The objective of this review is to provide a current overview of the rapidly developing chemistry of organometallic complexes and particularly organoiron complexes useful in asymmetric and stereoselective reactions. Also covered are stereoselective reactions of α, β-unsaturated acyl ligands bound to the chiral auxiliary [(η5-C5H5) Fe(CO)(PPh3)] and new applications of organoiron complexes in the synthesis of natural products. The mechanistic aspects and stabilizing effects of the Fe(CO)3 group for alkenes or conjugated dienes are discussed. A brief summary of recent work on the special role of iron in biological reactions is also included.

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Section: Synthesis Of Natural Products Via Iron Carbonylsmentioning

confidence: 99%