Ein Membranmodell für eine Reihe bioelektrischer Vorgänge

Labes, Richard; Zain, H.

doi:10.1007/bf01867212

Cited by 8 publications

(1 citation statement)

References 11 publications

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“…13 illustrates that, in asymmetrical NaCl solutions, these membranes exhibited significant rectifying properties. Similar observations have been made previously in comparable bilayer membranes by Cass et al (20) and in thicker inert membranes by others (11,21,22). The curves in Fig.…”

Section: G_ (Pdn/pdcl)axa + Acsupporting

confidence: 89%

Chloride Transport in Porous Lipid Bilayer Membranes

Andreoli

Watkins

1973

The Journal of General Physiology

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This paper describes dissipative C1-transport in "porous" lipid bilayer membranes, i.e., cholesterol-containing membranes exposed to 1-3 X 10 -7 M amphotericin B. PDC, (cm. s-), the diffusional permeability coefficient for C-, estimated from unidirectional 86Cl-fluxes at zero volume flow, varied linearly with the membrane conductance (Gm, -1' cm-2 ) when the contributions of unstirred layers to the resistance to tracer diffusion were relatively small with respect to the membranes; in 0.05 M NaCI, PDoI was 1.36 X 10-4 cm s -1 when Gm was 0.02 -1. cm-2. Net chloride fluxes were measured either in the presence of imposed concentration gradients or electrical potential differences. Under both sets of conditions: the values of PDCI computed from zero volume flow experiments described net chloride fluxes; the net chloride fluxes accounted for 90-95 % of the membrane current density; and, the chloride flux ratio conformed to the Ussing independence relationship. Thus, it is likely that C1-traversed aqueous pores in these anion-permselective membranes via a simple diffusion process. The zero current membrane potentials measured when the aqueous phases contained asymmetrical NaCl solutions could be expressed in terms of the Goldman-Hodgkin-Katz constant field equation, assuming that the PDN/PDC1 ratio was 0.05. In symmetrical salt solutions, the current-voltage properties of these membranes were linear; in asymmetrical NaCI solutions, the membranes exhibited electrical rectification consistent with constant-field theory. It seems likely that the space charge density in these porous membranes is sufficiently low that the potential gradient within the membranes is approximately linear; and, that the pores are not electrically neutral, presumably because the Debye length within the membrane phase approximates the membrane thickness.

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Section: G_ (Pdn/pdcl)axa + Acsupporting

confidence: 89%

Chloride Transport in Porous Lipid Bilayer Membranes

Andreoli

Watkins

1973

The Journal of General Physiology

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The influence of organic electrolytes and non‐electrolytes upon the membrane potentials of muscle and nerve

Höber

Andersh

Höber

et al. 1939

J. Cell. Comp. Physiol.

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FOUR FIGURES IKTEODUCTIOSIn 1880, Biedermann observed that, after having placed two leads with NaCl in contact with two points of an uninjured frog sartorius, a resting potential of the order of tens of millivolts develops, when NaCl on one lead is substituted by KC1. RC1 yields an electronegativity which is similar to that obtained when a muscle is cut. The KCl effect, however, is reversible. Twenty-five years later, Hober ( '05 ; Seo, '24) investigated the electromotive effect of a great number of other inorganic salts with the following result in regard to neutral alkali salts.With change in cation, the negativity decreased in the order: I<, Rb, NH,, Cs, Na, Li, while changing the anion yielded the order: SO,, Cl, Br, J, SCN. The anion effect was small in comparison to the cation effect. More recently, a corresponding effect of these salts on frog sciatic has been observed by Netter ('28), and on crab nerve by Wilbrandt ( '37) aind Cowan ( '34). There is only a quantitative difference in these tissues, the anions having still less effect on crab nerve than on frog muscle, while the effect on frog nerve is almost though not entirely lacking. All the electromotive effects mentioned are more or less reversible. The potential measurements on frog muscle, for the first time, provided evidence for a connection between the resting potential and excitability. The great and rapid decrease of excitability, produced by immersion of the uninjured muscle into different alkali salt solutions (Overton, '04; Schwarz, '07) is paralleled by the large and rapid increase of negativity caused by local application of the salts to the muscle. Preliminary reports have been published in the

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Pharmakologische Untersuchungen über die Teilprozesse des Nervenerregungsvorganges

Labes

1932

Archiv f. experiment. Pathol. u. Pharmakol

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Ein Membranmodell für eine Reihe bioelektrischer Vorgänge

Cited by 8 publications

References 11 publications

Chloride Transport in Porous Lipid Bilayer Membranes

Chloride Transport in Porous Lipid Bilayer Membranes

The influence of organic electrolytes and non‐electrolytes upon the membrane potentials of muscle and nerve

Pharmakologische Untersuchungen über die Teilprozesse des Nervenerregungsvorganges

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