Ein einfach herzustellender elektrochemischer Flussmikroreaktor: effiziente Isoindolinon‐Synthese und Funktionalisierung im Fluss

Folgueiras‐Amador, Ana A.; Philipps, Kai; Guilbaud, Sébastien; Poelakker, Jarno; Wirth, Thomas

doi:10.1002/ange.201709717

Cited by 38 publications

(2 citation statements)

References 56 publications

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“…Minimizing the electrodes and their inter-electrode distances can enhance the inter-electrode material exchange. 81 In addition, the number of electrons required to complete an electrochemical reaction is proportional to moles of substrate, and, thus, reducing the amount of substrate used during the screening can reduce needed electrons, which can shorten the reaction time. 82 Thus, developing the miniaturization tools for electrochemistry screening is crucial to achieve a throughput that, otherwise, is hard to realize using conventional devices.…”

Section: Miniaturization Of Screening Devicesmentioning

confidence: 99%

Accelerated Electrosynthesis Development Enabled by High-Throughput Experimentation

Chen

2023

Synthesis

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Electrochemical synthesis has recently emerged as an environmentally benign method for synthesizing value-added fine chemicals. Its unique reactivity has attracted significant interests of synthetic chemists to develop new redox chemistries. However, compared to conventional chemistry, the increased complexity caused by electrode materials, supporting electrolytes, and setup configurations create obstacles for efficient reaction discovery and optimization. The recent increasing adoption of high-throughput experimentation (HTE) in synthetic chemistry significantly expedites the synthesis development. Considering the potential of implementing HTE in electrosynthesis to tackle the challenges of increased parameter space, this short review aims at providing recent advances in the HTE technology for electrosynthesis, including electrocatalysts screening, device miniaturization, electroanalytical methods, artificial intelligence, and system integration. The discussed contents also cover some topics in HTE electrochemistry for areas other than synthetic chemistry, hoping to spark some inspirations for readers to use interdisciplinary techniques to solve challenges in synthetic electrochemistry.

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Section: Miniaturization Of Screening Devicesmentioning

confidence: 99%

Accelerated Electrosynthesis Development Enabled by High-Throughput Experimentation

Chen

2023

Synthesis

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“…Meanwhile, Wu and Rao independently reported visible‐light mediated synthesis of sulfonylated phthalides with Ir(ppy) 3 photocatalyst [12] . Synthesis of TEMPO coupled isoindolin‐1‐ones from 2‐alkenylbenzamides via flow‐electrolysis was investigated by Wirth [13] . More recently, Liu reported the synthesis of selenylated isoindolin‐1‐ones through visible light‐mediated photocatalysis with diselenides and 2‐alkenylbenzamides [14] …”

Section: Introductionmentioning

confidence: 99%

Metal‐ and Oxidant‐Free Electrosynthesis of Heterocycles from 1,2‐Diarylalkene Derivatives

Park

Kim

2022

Adv Synth Catal

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Synthesis of heterocycles from 1,2‐diarylalkene derivatives through electrosynthesis under metal‐ and oxidant‐free conditions has been discovered. Cathodic reduction of 2‐alkenylbenzoic acid or anodic oxidation of 2‐alkenylbenzamide, 2‐alkenylphenol and 2‐alkenylaniline leads to the formation of reactive radical intermediates which afford corresponding phthalide, isochroman‐1‐one, isoindolin‐1‐one, benzofuran, and indole in satisfying yields with good functional group tolerance. Interestingly, different chemoselectivities were found in different reaction solvents. Several mechanistic investigations including cyclic voltammetry studies and control experiments were carried out to elucidate the reaction mechanisms.

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Electrochemical Generation of N‐Heterocyclic Carbenes for Use in Synthesis and Catalysis

et al. 2021

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The electrochemical generation of N‐heterocyclic carbenes (NHCs) offers a mild and selective alternative to traditional synthetic methods that usually rely on strong bases and air‐sensitive materials. The use of electrons as reagents results in an efficient and clean synthesis that enables the direct use of NHCs in various applications. Herein, the use of electrogenerated NHCs in organocatalysis, synthesis and organometallic chemistry is explored.

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Ein einfach herzustellender elektrochemischer Flussmikroreaktor: effiziente Isoindolinon‐Synthese und Funktionalisierung im Fluss

Cited by 38 publications

References 56 publications

Accelerated Electrosynthesis Development Enabled by High-Throughput Experimentation

Accelerated Electrosynthesis Development Enabled by High-Throughput Experimentation

Metal‐ and Oxidant‐Free Electrosynthesis of Heterocycles from 1,2‐Diarylalkene Derivatives

Electrochemical Generation of N‐Heterocyclic Carbenes for Use in Synthesis and Catalysis

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