Ein Beitrag zur Physiologie und zum Wirt-Parasit-Verhältnis von Graphidium strigosum (Trichostrongylidae, Nematoda)

Ënigk, K.

doi:10.1007/bf02123447

Cited by 13 publications

(20 citation statements)

References 14 publications

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“…Results obtained by us were comparable to the 5 weeks reported by Cabaret (1981) or the 40-60 days range reported by Nickel and Haupt (1986) but not with those indicated by the exhaustive work of Enigk (1938;12-35 days).…”

Section: Discussionsupporting

confidence: 79%

“…The pattern of fecal egg output by infected rabbits has been only partially studied but the increase in epg counts during the experimental period (12 weeks) supports the results obtained by Enigk (1938), who found a peak period between 5-15 weeks pi.…”

Section: Discussionsupporting

confidence: 74%

“…Infections by this nematode are frequent in leporids (Massone et al 2003;Lello et al 2004;Wibbelt and Frölich 2005). However, the information on the endogenous life cycle of this helminth and the possible pathology involved is scarce and inconsistent (Enigk 1938;Cabaret 1981;Nickel and Haupt 1986) and no data are available on the immune response elicited by the infections.…”

Section: Introductionmentioning

confidence: 99%

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Immunobiological characterization of Graphidium strigosum experimental infection in rabbits (Oryctolagus cuniculus)

Cuquerella

Alunda

2008

Parasitol Res

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An experimental infection of rabbits with a wild isolate of the gastric nematode Graphidium strigosum was carried out. Animals (3.5 months age) were infected with 1,000 L3 administered by bucoesophagic catheter (five rabbits) or kept as uninfected control group (five animals). The infection was maintained for 3 months. Along the experimental period, some parasitological, hematological and immunological parameters were determined. Prepatent period of the infection ranged from 30 to 38 days and, at necropsy, average adult helminth counts were 430.75 +/- 126.12. No significant variations were found in packed cell volume, leukocyte, and eosinophil counts along the experimental period. Infection elicited a clear serum-specific IgG response, estimated by ELISA, during patency. Pooled sera from the patent period of the infection recognized some soluble antigens, particularly, a 67-kDa protein. Experimentally infected animals did not show cross recognition between G. strigosum, Haemonchus contortus, and Teladorsagia circumcincta. However, Western blot analysis with hyperimmune sera against H. contortus raised in rabbits and lambs showed cross reactivity between this helminth species and G. strigosum.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Immunobiological characterization of Graphidium strigosum experimental infection in rabbits (Oryctolagus cuniculus)

Cuquerella

Alunda

2008

Parasitol Res

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“…According to recent reports, the trypanocidal compound "Berenil" has been successfully used in the treatment of bovine, ovine, and canine piroplasmoses in the field (Bauer, 1955;Enigk and Reusse, 1955). SUMMARY 1.…”

Section: Resultsmentioning

confidence: 99%

“…The control animals generally showed a parasitaemia of 70-80% at this time and they usually died from the infection on or about the eighth day. The blood of mice which survived for eight days or longer was examined at weekly intervals for a further four weeks in order to follow the course of infection.The drugs used were (a) antimalarial compounds chloroquine diphosphate; mepacrine hydrochloride; pamaquin naphthoate; proguanil acetate; pyrimethamine; (b) trypanocidal compounds: antrycide methyl sulphate; " Berenil," di-(4-amidinophenyl)-triazene-(N-1:3) diaceturate-3H2O (Milne, Robson, and Lwebandiza, 1955;Bauer, 1955;Enigk and Reusse, 1955); B314, 2-p-acetaminostyryl-6-methylaminoquinoline methosulphate (Browning, Cohen, Ellingworth, and Galbransen, 1929); "Congasin," bis-2-methyl-4-aminoquinolyl-6-melamine; ethidium bromide; RD 1660, l-methyl-l-phenyl dithiobiuret (Woolfe, 1953); the antibiotic "Stylomycin" (Porter et al, 1952); suramin; tartar emetic; tryparsamide. All drugs were dissolved in sterile saline or sterile distilled water.…”

mentioning

confidence: 99%

THE ACTION OF SOME TRYPANOCIDAL AND ANTIMALARIAL COMPOUNDS ON BABESIA RODHAINI (PIROPLASMIDEA)

Terry

Godfrey

1956

British Journal of Pharmacology and Chemotherapy

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This paper describes an investigation into the effects of a series of well-known trypanocidal and antimalarial compounds on the course of infection with the piroplasm Babesia rodhaini in white mice.B. rodhaini was isolated from the blood of the rodent Thamnomys surdaster surdaster by van den Berghe, Vincke, Chardome, and van den Bulke (1950). The organism was transmitted to white mice and is now maintained in these animals. B. rodhaini promised to be a useful organism for the screening of drugs designed for the treatment of piroplasmosis; the results of some investigations in this field have already been published (Rodhain. 1951; Beveridge, 1953).During the course of other work with B. rodhaini in this laboratory, it was discovered that infections could be cured with the trypanocidal compounds antrycide and 1-methyl-l-phenyldithiobiuret (Godfrey, 1955), whereas the antimalarial drugs mepacrine and proguanil were without effect. This result is surprising when it is considered that the Piroplasmidea are much more nearly related to the Haemosporidiidea than they are to the Trypanosomidae. Accordingly, it was decided to investigate the action upon B. rodhaini of a series of compounds which were known to have either trypanocidal or plasmodicidal properties. METHODSThe strain of B. rodhaini used was the Antwerp strain, obtained through the courtesy of Miss E. Beveridge, of the Wellcome Laboratories of Tropical Medicine. The method of testing the drugs against B. rodhaini was adapted from the standard screening procedure used in our laboratories. White mice were inoculated intraperitoneally with three million parasitized erythrocytes contained in 0.2 ml. of citrated saline, and were then treated daily with the drug for four days, the first dose being given intraperitoneallyfour hours after infection. Thin blood films were made on the sixth day, stained with Giemsa, and the percentages of parasitized erythrocytes were recorded. The control animals generally showed a parasitaemia of 70-80% at this time and they usually died from the infection on or about the eighth day. The blood of mice which survived for eight days or longer was examined at weekly intervals for a further four weeks in order to follow the course of infection.The drugs used were (a) antimalarial compounds chloroquine diphosphate; mepacrine hydrochloride; pamaquin naphthoate; proguanil acetate; pyrimethamine; (b) trypanocidal compounds: antrycide methyl sulphate; " Berenil," di-(4-amidinophenyl)-triazene-(N-1:3) diaceturate-3H2O (Milne, Robson, and Lwebandiza, 1955;Bauer, 1955;Enigk and Reusse, 1955); B314, 2-p-acetaminostyryl-6-methylaminoquinoline methosulphate (Browning, Cohen, Ellingworth, and Galbransen, 1929); "Congasin," bis-2-methyl-4-aminoquinolyl-6-melamine; ethidium bromide; RD 1660, l-methyl-l-phenyl dithiobiuret (Woolfe, 1953); the antibiotic "Stylomycin" (Porter et al., 1952); suramin; tartar emetic; tryparsamide. All drugs were dissolved in sterile saline or sterile distilled water. The chronic toxicity of each drug was estimated by intrap...

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Magen-Darmhelminthen und Kokzidien beim Feldhasen (Lepus europaeus Pallas) und ihre Bekämpfung mit Thibenzole® und Theracanzan®

Barth¹,

Brüll²

1975

Zeitschrift für Jagdwissenschaft

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Ein Beitrag zur Physiologie und zum Wirt-Parasit-Verhältnis von Graphidium strigosum (Trichostrongylidae, Nematoda)

Cited by 13 publications

References 14 publications

Immunobiological characterization of Graphidium strigosum experimental infection in rabbits (Oryctolagus cuniculus)

Immunobiological characterization of Graphidium strigosum experimental infection in rabbits (Oryctolagus cuniculus)

THE ACTION OF SOME TRYPANOCIDAL AND ANTIMALARIAL COMPOUNDS ON BABESIA RODHAINI (PIROPLASMIDEA)

Magen-Darmhelminthen und Kokzidien beim Feldhasen (Lepus europaeus Pallas) und ihre Bekämpfung mit Thibenzole® und Theracanzan®

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