Eikenella corrodens endocarditis and liver abscess in a previously healthy male, a case report

Abstract

BackgroundEikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male.Case presentationA 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests. Initially pneumonia was suspected, but due to lack of improvement on pneumonia treatment, a PET-CT scan was performed, which showed a large multiloculated abscess in the liver. The abscess was drained using ultrasound guidance. Culture demonstrated Eikenella corrodens. Transesophageal echocardiography revealed aortic endocarditis. The patient was treated with antibiotics and abscess drainage, on which he slowly improved. He was discharged after 1.5 months of hospitalisation. On follow-up 2 months later, the patient was asymptomatic with normalized biochemistry and ultrasound showed complete regression of the abscess.ConclusionsThis is the first case of documented Eikenella corrodens concurrent liver abscess and endocarditis. The case report highlights that Eikenella corrodens should be considered as a cause of liver abscess. Empirical treatment of pyogenic liver abscess will most often cover Eikenella corrodens, but the recommended treatment is a third generation cephalosporin or a fluoroquinolon. A multiloculated liver abscess may require drainage several times during treatment. The finding of Eikenella corrodens should elicit an echocardiography to diagnose endocarditis even in patients without clinical signs of endocarditis.

The Oral Bacterial Microbiome of Interdental Surfaces in Adolescents According to Carious Risk

“…R. dentocariosa and S. mutans are known to be associated with bacteraemia and infective endocarditis [118,119]. E. corrodens has been described in cardiovascular diseases (CVD) [120,121], and C. ochracea has also been described in lupus [122,123]. F. nucleatum has been related to CVD, Alzheimer′ s, and adverse pregnancy [124].…”

Secondary hand infection with Eikenella corrodens and Staphylococcus aureus in a patient with Behcet's disease: a case report

“…Infections primarily occur in the head, neck, pharynx and are associated with conditions such as pleurisy, thyroiditis, meningitis, liver abscesses, hip arthritis, and knee arthritis. 3 – 12 E. corrodens is easily missed from routine cultures because of its biological characteristics. Here, we report a case of a serious secondary hand infection in a patient with BD caused by E. corrodens and Staphylococcus aureus coinfection.…”

Epidural Abscess Caused byEikenella corrodensin a Previously Healthy Child

“…Eikenella species is known to cause central nervous system (CNS) infection, sinusitis, endocarditis, intraabdominal infection, liver abscess, and osteomyelitis in adults. 2,3) However, E. corrodens infection in children and adolescents have rarely been reported and clinical characteristics of Eikenella infections in children are not well described. 4) Here, we report a case of E. corrodens epidural abscess complicated by sinusitis in a previously healthy 13-year-old boy who recovered after management with antibiotics and surgery.…”