Eight Weeks of Exercise Training Increases Aerobic Capacity and Muscle Mass and Reduces Fatigue in Patients With Cirrhosis

Zenith, Laura; Meena, Neha; Ramadi, Ailar; Yavari, Milad; Harvey, Andrea; Carbonneau, Michelle; Ma, Mang; Abraldes, Juan G.; Paterson, Ian; Haykowsky, Mark J.; Tandon, Puneeta

doi:10.1016/j.cgh.2014.04.016

Cited by 186 publications

(214 citation statements)

References 33 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…Even though some studies did not find a negative correlation between exercise capacity and Child-Pugh scoring (21,22,34,35), it has been suggested that hepatic cirrhosis can affect cardiorespiratory capacity during exercise (24,25,27,28,30,32).…”

Section: Methodsmentioning

confidence: 99%

“…Zenith et al (34) concluded that this paucity of data may be mostly related to extreme concerns about safety precautions of training intervention applied to this population. In agreement to the findings of this study, other two investigations, (34,35) with a larger sample demonstrated a significant increase in VO 2peak after aerobic training. Interestingly, exercise improved also muscle mass, besides cardiorespiratory capacity.…”

Section: Methodsmentioning

confidence: 99%

“…Not much is known about training effects on people who have severe hepatic disease (22,34,35). Campillo et al (22) was the first study to perform aerobic training on 4 patients.…”

Section: Methodsmentioning

confidence: 99%

“…The exercise capacity of subjects with hepatic cirrhosis was assessed using oxygen consumption on maximum cardiopulmonary tests on fifteen different articles (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). These studies are described on table 1.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

The influence that hepatic cirrhosis provides in exercise capacity and muscle strength: a review

2015

View full text Add to dashboard Cite

Introduction: Hepatic cirrhosis leads to a series of physiological changes, among which stand out cardiorespiratory and muscle impairments. These changes determine a negative impact on quality of life and may cause physical inactivity. Objective: The objective of this study was to review, in the most current scientific literature, the influence that hepatic cirrhosis provides in exercise capacity and muscle strength, and the effect of exercise when applied to this situation. Materials and methods: For this review, research on original studies was carried out on Medical Literature Analysis and Retrieval System Online (assessed by PubMed), Scopus and Web of Science between the years 1990 to 2015. In order to be included, studies had to meet the following criteria: a) be from original articles; b) evaluate exercise capacity or muscle strength; and c) provide relevant results. Results and Discussion: The majority of studies concluded that the exercise capacity and muscle strength are decreased in individuals with cirrhosis when compared to control subjects.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Not much is known about training effects on people who have severe hepatic disease (22,34,35). Campillo et al (22) was the first study to perform aerobic training on 4 patients.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The influence that hepatic cirrhosis provides in exercise capacity and muscle strength: a review

2015

View full text Add to dashboard Cite

show abstract

“…In a recent prospective pilot study by Zenith et al, eight weeks of supervised aerobic exercise training increased muscle mass, expressed as thigh circumference, and reduced fatigue in 8 patients with Child-Pugh class A or B cirrhosis (Zenith et al 2014). Another recent randomized pilot study including cirrhotic patients, Child-Pugh grade A or B, examined whether an exercise programme combined with leucine supplementation might improve patient outcome over a period of 12 weeks.…”

mentioning

confidence: 97%

What is new about diet in hepatic encephalopathy

2015

View full text Add to dashboard Cite

There is a relationship between hepatic encephalopathy (HE) protein malnutrition and muscle wasting. Muscle may play an alternative role in ammonia detoxification. Molecular mechanisms responsible for muscle depletion are under investigation. Specific nutrients may interact to reverse the molecular pathways involved in muscle wasting at an early stage. Training exercises have also been proposed to improve skeletal muscle mass. However, these data refer to small groups of patients. The amelioration of muscle mass may potentially help to prevent HE. The pathogenesis of HE is associated with modifications of the gut microbiota and diet is emerging to play a relevant role in the modulation of the gut milieu. Vegetarian and fibre-rich diets have been shown to induce beneficial changes on gut microbiota in healthy people, with reduction of Bacteroides spp., Enterobacteriaceae, and Clostridium cluster XIVa bacteria. By way of contrast, it has been suggested that a high-fat or protein diet may increase Firmicutes and reduce Bacteroidetes phylum. Milk-lysozyme and milk-oligosaccharides have also been proposed to induce a "healthy" microbiota. At present, no studies have been published describing the modification of the gut microbiota in cirrhotic patients with HE as a response to specific diets. New research is needed to evaluate the potentiality of foods in the modulation of gut microbiota in liver disease and HE.

show abstract