Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia

Su, Xiuqin; Li, Li; Sun, Hua; Zhang, Fan; Li, Changkang; Li, Fenghua; Wang, Hongqing; Li, Baoming; Chen, Ruo-Yun; Kang, Jie

doi:10.1016/j.bioorg.2018.11.055

Cited by 9 publications

(2 citation statements)

References 28 publications

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“…There exist now three possibilities how the additional glucose and the ferulic acid are linked to the glucose. One possibility is isorhamnetin-3-glu-glu-ferulic acid [ 63 ] and the other isorhamnetin-3-(2″-glu-ferulic acid)-glu [ 64 ], both of which were elucidated by 2D-NMR techniques. However, in consideration of a simple way to convert this ferulic acid–isorhamnetin glycoside to the structure of the one eluting at 9.50 min, isorhamnetin-3-glu-ferulic acid-7-glu, the structure of isorhamnetin-3-(2″-glu)-glu-ferulic acid is proposed.…”

Section: Resultsmentioning

confidence: 99%

Secondary or Specialized Metabolites, or Natural Products: A Case Study of Untargeted LC–QTOF Auto-MS/MS Analysis

Hadaček

2022

Cells

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The large structural diversity of specialized metabolites represents a substantial challenge in untargeted metabolomics. Modern LC–QTOF instruments can provide three- to four-digit numbers of auto-MS/MS spectra from sample sets. This case study utilizes twelve structurally closely related flavonol glycosides, characteristic specialized metabolites of plant tissues, some of them isomeric and isobaric, to illustrate the possibilities and limitations of their identification. This process requires specific software tools that perform peak picking and feature alignment after spectral deconvolution and facilitate molecular structure base searching with subsequent in silico fragmentation to obtain initial ideas about possible structures. The final assignment of a putative identification, so long as spectral databases are not complete enough, requires structure searches in a chemical reference database, such as SciFindern, in attempts to obtain additional information about specific product ions of a metabolite candidate or check its feasibility. The highlighted problems in this process not only apply to specialized metabolites in plants but to those occurring in other organisms as well. This case study is aimed at providing guidelines for all researchers who obtain data from such analyses but are interested in deeper information than just Venn diagrams of the feature distribution in their sample groups.

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Section: Resultsmentioning

confidence: 99%

Secondary or Specialized Metabolites, or Natural Products: A Case Study of Untargeted LC–QTOF Auto-MS/MS Analysis

Hadaček

2022

Cells

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“…is a perennial liana or creeping shrub of the family Rubiaceae, which grows at sparse forests or forest margins in southeastern Asia, including the south of China, Vietnam, and Philippines (Chen and Taylor 2011). It is used as a traditional medicine in the treatment of tracheitis, coughing and dyspepsia (Su et al 2019), which contains the compounds of quinones, flavonoid glycosides, and terpenoids, etc (Chang et al 1982;Chang and Lee 1984;Kang et al 2016). However, recently, overexploitation has adversely affected its natural distribution, population, and habitat.…”

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confidence: 99%

Complete chloroplast genome of Morinda parvifolia (Rubiaceae), a traditional medicinal plant in China

Cai

Tarin

Fan

et al. 2020

Mitochondrial DNA Part B

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Morinda parvifolia is a traditional medicinal plant of the family Rubiaceae. In the current study, the complete chloroplast genome of M. parvifolia was sequenced and reported for the first time. The genome is 153,069 bp in total length, containing two inverted repeats (IR) regions of 25822 bp which were separated by a large single copy (LSC) region of 83813 bp and a small single copy (SSC) region of 17612 bp. A total of 131 gene species were annotated, including 86 protein-coding genes,37 tRNA genes, and 8 rRNA genes. The overall GC content of the genome is 38.07%. The phylogenetic analysis based on the complete chloroplast genome reveals that M. parvifolia is closely related to Morinda officinalis. This study enriches the genetic information of M. parvifolia as well as for the phylogenetic studies for Rubiaceae.

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Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia

Cited by 9 publications

References 28 publications

Secondary or Specialized Metabolites, or Natural Products: A Case Study of Untargeted LC–QTOF Auto-MS/MS Analysis

Secondary or Specialized Metabolites, or Natural Products: A Case Study of Untargeted LC–QTOF Auto-MS/MS Analysis

Complete chloroplast genome of Morinda parvifolia (Rubiaceae), a traditional medicinal plant in China

Indian Morinda species: A review

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