Eight-month functional outcome from mania following a first psychiatric hospitalization

Strakowski, Stephen M.; Williams, J.R.; Fleck, David E.; DelBello, Melissa P.

doi:10.1016/s0022-3956(00)00015-7

Cited by 87 publications

(58 citation statements)

References 13 publications

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“…Socioeconomic status was ascertained using the 4-factor Hollingshead Scale (24). Premorbid psychosocial function (highest level during the year prior to index hospitalization) was assessed using the functional rating scales of the Longitudinal Interval Follow-up Examination (LIFE) (25,26). Trained raters with good interrater reliability (kappa>0.75) evaluated four major areas of functioning: role performance, interpersonal relationships, recreational enjoyment, and sexual activity.…”

Section: Index Assessmentsmentioning

confidence: 99%

“…The outcome assessments have been described elsewhere (13,(25)(26)(27)(28) and are based on the National Institute of Mental Health (NIMH) Multisite Collaborative Study (29). At each follow-up visit, the investigators reviewed affective symptoms during the prior interval, week-by-week, with the adolescent and their primary caregivers.…”

Section: Outcome Assessmentsmentioning

confidence: 99%

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Twelve-Month Outcome of Adolescents With Bipolar Disorder Following First Hospitalization for a Manic or Mixed Episode

DelBello

Hanseman

Adler

et al. 2007

AJP

251

142

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Most bipolar adolescents experienced syndromic recovery following their first hospitalization. However, rates of symptomatic and functional recoveries were much lower. Future studies examining effective pharmacological and nonpharmacological treatment strategies for bipolar youth with co-occurring disorders and investigating factors that contribute to the development of substance use disorders and treatment adherence in bipolar youth are necessary to improve outcome.

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Section: Index Assessmentsmentioning

confidence: 99%

Section: Outcome Assessmentsmentioning

confidence: 99%

Twelve-Month Outcome of Adolescents With Bipolar Disorder Following First Hospitalization for a Manic or Mixed Episode

DelBello

Hanseman

Adler

et al. 2007

AJP

251

142

View full text Add to dashboard Cite

show abstract

“…More recently, a few studies that have examined course and outcome of BD in patients who have recently had their first manic episode showed that, like first-episode schizophrenia, first-episode mania carries with it a high risk of poor functional outcome. 8,9 These studies also reported a high risk of suicide, high prevalence of comorbid diagnoses, and worse outcome with earlier age at onset. [10][11][12] A large retrospective study, which included 20 350 patients with affective disorders after their first hospital admission, showed that bipolar patients had a higher risk of recurrence than those with major depressive disorder.…”

mentioning

confidence: 99%

Course and Outcome after the First Manic Episode in Patients with Bipolar Disorder: Prospective 12-Month Data from the Systematic Treatment Optimization Program for Early Mania Project

et al. 2009

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Objective: To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD).Methods: This paper describes the project design, demographics, clinical outcomes, and predictors at 6 months to 1 year of follow-up of the first 53 recruited subjects with first-episode mania from the Systematic Treatment Optimization Program for Early Mania.Results: Survival analysis for recurrence of mood episodes showed that 46.7% of patients survived without a mood episode during 1-year of follow-up, and the mean time-to-mood event was 7.9 months. Earlier age of onset was the only variable that significantly predicted recurrence of mood episodes. When examined separately, the survival rates were 76% for a manic episode and 58.7% for a depressive episode. Conclusion:These results suggest that recurrences are common after the first manic episode with more than one-half of the patients experiencing a mood event within 12 months. Aggressive treatment strategies aimed at preventing depressive episodes are needed in the management of early course BD.Can J Psychiatry. 2009;54(2):105-112. Clinical Implications· Depressive recurrences are common after the first manic episode and deserve special clinical attention. · Younger age at onset of mood episodes was significantly associated with worse outcome, reinforcing the need for preventive strategies. · As these patients received comprehensive treatments, the data suggests that currently available treatments are not adequate in preventing depression for a significant proportion of patients. Limitations· The sample size may have restricted the ability to detect smaller effect sizes of other predictors of recurrence. · This study design does not allow an assessment of the impact of different treatments on outcome. · The relatively shorter period of follow-up limits the conclusions about outcome to the early recovery phase of BD.

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“…Bipolar illness is a lifelong psychiatric disorder which may carry severe impairment of patients' general functioning (Strakowski et al 2000, Goldberg & Harrow 2004. In 1990, the World Health Organization studies reported that bipolar disorder is the sixth leading cause of worldwide disability (Lopez & Murrray 1998, World Health Organization 1999.…”

Section: Introductionmentioning

confidence: 99%

The impact of the number of episodes on the outcome of Bipolar Disorder

et al. 2006

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-Background: Bipolar disorder is a highly recurrent severe psychiatric disorder. The number of episodes has been found consistently associated with poor outcome. It has been suggested that bipolar patients with long duration of illness and highly recurrent course show great impairment of global functioning.Objectives: The aim of this study is to assess the clinical course and outcome of patients with bipolar disorder I and II with a high number of mood episodes.Methods: We compared a group of bipolar I and II subjects whose number of episode was higher than ten (N = 167) with a similar-size representative sample of bipolar patients whose number of episodes was lower or equal than ten (N = 131).Results: Bipolar patients with more than 10 episodes have a more severe outcome of bipolar disorder. Qualification and occupational status was clearly worse for the highly recurrent group which showed a predominance of depressive polarity.Conclusions: These data suggest that bipolar patients with a highly recurrent course have significant functional impairment. With the passing of time, bipolar illness tends to be ruled by depressive features. Treatment strategies may need to address this issue.

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Eight-month functional outcome from mania following a first psychiatric hospitalization

Cited by 87 publications

References 13 publications

Twelve-Month Outcome of Adolescents With Bipolar Disorder Following First Hospitalization for a Manic or Mixed Episode

Twelve-Month Outcome of Adolescents With Bipolar Disorder Following First Hospitalization for a Manic or Mixed Episode

Course and Outcome after the First Manic Episode in Patients with Bipolar Disorder: Prospective 12-Month Data from the Systematic Treatment Optimization Program for Early Mania Project

The impact of the number of episodes on the outcome of Bipolar Disorder

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