Eight Genome Sequences of Cluster BE1 Phages That Infect
            <i>Streptomyces</i>
            Species

Hughes, Lee E.; Shaffer, C.; Ware, Vassie C.; Aguayo, Issac; Aziz, Rahat M.; Bhuiyan, Swapan; Bindert, Isaac S.; Calovich-Benne, Canyon; Chapman, J.F.; Donegan-Quick, Richard; Farooq, Amal; Garcia, Cynthia; Graham, Lee H.; Green, Baylee Y.; Kenna, Margaret A.; Kneeream, Emily R.; Laing, Christian; Mageeney, Catherine M.; Meridew, Sandra N.; Mikolon, Abigail R.; Morgan, Ryann E.; Nayek, Subhayu; Olugbade, Idowu D.; Pike, Kim C.; Schlegel, Lauren E.; Shishido, Taylor C.; Suresh, Tara; Suri, Nikita; Hafer, Kathleen Weston; Garlena, Rebecca A.; Russell, Daniel A.; Cresawn, Steven G.; Pope, Welkin H.; Jacobs-Sera, Deborah; Hatfull, Graham F.

doi:10.1128/genomea.01146-17

Cited by 2 publications

(2 citation statements)

References 9 publications

(9 reference statements)

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“…The determination of protein pairwise identities between copies encoded in the same genome revealed significant variation. Interestingly, Arthrobacter and Streptomyces phage Lsr2 protein copies shared 100% of sequence identity, which is because the corresponding genes are located within the direct terminal repeats (DTR) of these phage genomes ( 29 ) (Fig. S8).…”

Section: Resultsmentioning

confidence: 99%

“…Remarkably, in Streptomyces phages belonging to the BE cluster, the lsr2 genes are located within the direct terminal repeat regions. The direct terminal repeats of BE cluster phages (10 to 12 kbp) are the longest found in actinobacteriophages to date ( 29 ). The genome alignment and GC content comparison of the lsr2 extended genomic loci from Streptomyces phage Coruscant against phage Mildred21 (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

et al. 2021

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Simultaneous entry as an adaptation to virulence in a novel satellite-helper system infecting Streptomyces species

deCarvalho,

Mascolo,

Caruso

et al. 2023

The ISME Journal

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Satellites are mobile genetic elements that are dependent upon the replication machinery of their helper viruses. Bacteriophages have provided many examples of satellite nucleic acids that utilize their helper morphogenic genes for propagation. Here we describe two novel satellite-helper phage systems, Mulch and Flayer, that infect Streptomyces species. The satellites in these systems encode for encapsidation machinery but have an absence of key replication genes, thus providing the first example of bacteriophage satellite viruses. We also show that codon usage of the satellites matches the tRNA gene content of the helpers. The satellite in one of these systems, Flayer, does not appear to integrate into the host genome, which represents the first example of a virulent satellite phage. The Flayer satellite has a unique tail adaptation that allows it to attach to its helper for simultaneous co-infection. These findings demonstrate an ever-increasing array of satellite strategies for genetic dependence on their helpers in the evolutionary arms race between satellite and helper phages.

show abstract

Eight Genome Sequences of Cluster BE1 Phages That Infect Streptomyces Species

Cited by 2 publications

References 9 publications

Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

Simultaneous entry as an adaptation to virulence in a novel satellite-helper system infecting Streptomyces species

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