Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies

Abstract

Levels of Lp-PLA2 mass and activity were associated with PLA2G7, the gene coding for this protein. Lipoprotein-associated phospholipase A2 activity was also strongly associated with genetic variants related to low-density lipoprotein cholesterol levels.

Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2

“…Lp-PLA 2 mass was found to be regulated mainly by PLA2G7 , consistent with another report ( 57 ). Lp-PLA 2 activity was strongly associated with genetic variants involved in lipid metabolism ( 56 ). The fi ndings of this interesting study suggest that genetic regions known to affect lipoprotein levels also infl uence Lp-PLA 2 expression.…”

“…A recent genome-wide association study that included fi ve population-based reports comprising 13,664 subjects identifi ed eight genetic loci associated with variation in Lp-PLA 2 mass and activity ( 56 ). Lp-PLA 2 mass was found to be regulated mainly by PLA2G7 , consistent with another report ( 57 ).…”

“…In a Taiwanese cohort, A379V was associated with increased risk of MI and increased severity of CAD ( 138 ). In contrast, a study of European Caucasians revealed reduced risk of MI in homozygotes for A379V ( 158 ), but metaanalyses of European Caucasian populations reported no association with CHD risk ( 56,156 ). In South Koreans, a similar lack of association between A379V and CVD disease was reported ( 137 ).…”

Genome-Wide Association Study Evaluating Lipoprotein-Associated Phospholipase A 2 Mass and Activity at Baseline and After Rosuvastatin Therapy

“…More recently, a genomewide meta-analysis of 13 664 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE, which includes the FHS) Consortium identified genome-wide associations for the same variants, in addition to CETP for Lp-PLA 2 mass and PLA2G7 and LDLR for Lp-PLA 2 activity. 15 Variants in the loci identified through the FHS GWAS and the CHARGE meta-analysis are known to be involved in lipid metabolism and have been observed to strongly influence circulating levels of LDL-C and HDL-C.…”

Protective role of Lipoprotein-Associated Phospholipase A2 Gene (A379V) Polymorphism against Myocardial Infarction among Egyptians

“…23 But other studies on european Caucasians reported no association with CHd risk. 16,28 In south Koreans, a similar lack of association between A379V and CVd was reported. 19 personalized medicine is of growing interest, with a number of pharmacogenetic drug examples, like clopedogril and warfarin, where genetic variants influence the rate of drug metabolism and efficacy.…”