Eight-and Twenty-Four-Hour Canine Pancreas Preservations Using a Simple Gel Cooling Technique

Serrou, B; Solassol, C; Michel, H; Gelis, C; Pujol, Hervé; Romieu, C

doi:10.1097/00007890-197311000-00002

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each configuration (hypothermia versus normothermia, continuous versus pulsatile, crystalloid and/or colloid perfusates versus blood, high-versus low-flow) has its own merits. Attempts to apply kidney perfusion technology to the pancreas have been unsuccessful [239,240,241,242,243,244,245,2461. Most studies used an allograft model and therefore only short-term function could be determined reliably.…”

Section: Machine Preservationmentioning

confidence: 99%

Technical aspects of islet preparation and transplantation

Lakey

Burridge

Shapiro

2003

Transplant International

View full text Add to dashboard Cite

The introduction of insulin therapy for the management of diabetes mellitus is arguably the greatest milestone in the history of modern medicine. P-cell replacement therapy is the only treatment that reestablishes and maintains longterm physiological normoglycemia. Until recently, successful clinical outcomes of pancreas transplantation for patients with long-standing diabetes were much superior to that of islet transplantation. Significant advances in islet isolation and purification technology, the development of more specific and less diabetogenic immunosuppressants and the prophylactic administration of antiviral agents have rekindled a worldwide interest in islet transplantation. This chapter will review the rationale of islet transplantation and the development of islet isolation and purification. The challenges facing clinical islet transplantation in the twenty-first century will also be introduced.

show abstract

Section: Machine Preservationmentioning

confidence: 99%

Technical aspects of islet preparation and transplantation

Lakey

Burridge

Shapiro

2003

Transplant International

View full text Add to dashboard Cite

show abstract

“…67 In this regard, it is interesting to note that previous experimental work highlighted the greater susceptibility of the cold preserved pancreas to developing edema during SCS and the importance of including a colloid in the preservation solution to achieve optimal postpancreas transplant outcomes. [68][69][70][71]…”

Section: Clinical Experiences With Modern Preservation Solutionsmentioning

confidence: 99%

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

et al. 2022

View full text Add to dashboard Cite

The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs. Perfusion is dynamic and offers several advantages in comparison with static cold storage. These include the ability to provide a continuous supply of new metabolic substrates, clear metabolic waste products, and perform some degree of organ viability assessment before actual transplantation in the recipient. At the same time, the ongoing importance of static cold storage cannot be overlooked, in particular when it comes to logistical and technical convenience and cost, not to mention the fact that it continues to work well for the majority of transplant allografts. The present review article provides an overview of the fundamental concepts of organ preservation, providing a brief history of static cold preservation and description of the principles behind and basic components of cold preservation solutions. An evaluation of current evidence supporting the use of different preservation solutions in abdominal organ transplantation is provided. As well, the range of solutions used for machine perfusion of abdominal organs is described, as are variations in their compositions related to changing metabolic needs paralleling the raising of the temperature of the perfusate from hypothermic to normothermic range. Finally, appraisal of new preservation solutions that are on the horizon is provided.

show abstract

Experimental Pancreas Transplantation

Toledo‐Pereyra¹

1988

Pancreas Transplantation

View full text Add to dashboard Cite

Eight-and Twenty-Four-Hour Canine Pancreas Preservations Using a Simple Gel Cooling Technique

Cited by 9 publications

References 0 publications

Technical aspects of islet preparation and transplantation

Technical aspects of islet preparation and transplantation

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

Experimental Pancreas Transplantation

Contact Info

Product

Resources

About