Eight- and six-coordinated Mn(II) complexes of heteroaromatic alcohol and aldehyde: Crystal structure, spectral, magnetic, thermal and antibacterial activity studies

Jabłońska-Wawrzycka, Agnieszka; Barszcz, Barbara; Zienkiewicz, Małgorzata; Hodorowicz, Maciej; Jezierska, Julia; Stadnicka, Katarzyna; Lechowicz, Łukasz; Kaca, Wiesław

doi:10.1016/j.saa.2014.03.105

Cited by 22 publications

(17 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of the Mn(II) ion with the ionic radius of 110 pm seems to confirm our suggestion. All the Mn-ligand distances, such as Mn-N 2.2711(1), 2.3176(2) Å, Mn-O 2.3032(1), and 2.3137(1) Å, are normal and comparable with the distances in other Mn(II) complexes containing the N,O-heteroaromatic ligands [29,31,47,48].…”

Section: Description Of the Molecular And Crystal Structurementioning

confidence: 60%

Tuning Anti-Biofilm Activity of Manganese(II) Complexes: Linking Biological Effectiveness of Heteroaromatic Complexes of Alcohol, Aldehyde, Ketone, and Carboxylic Acid with Structural Effects and Redox Activity

Jabłońska-Wawrzycka

Rogala

Czerwonka

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

The constantly growing resistance of bacteria to antibiotics and other antibacterial substances has led us to an era in which alternative antimicrobial therapies are urgently required. One promising approach is to target bacterial pathogens using metal complexes. Therefore, we investigated the possibility of utilizing series of manganese(II) complexes with heteroaromatic ligands: Alcohol, aldehyde, ketone, and carboxylic acid as inhibitors for biofilm formation of Pseudomonas aeruginosa. To complete the series mentioned above, Mn-dipyCO-NO3 with dipyridin-2-ylmethanone (dipyCO) was isolated, and then structurally (single-crystal X-ray analysis) and physicochemically characterized (FT-IR, TG, CV, magnetic susceptibility). The antibacterial activity of the compounds against representative Gram-negative and Gram-positive bacteria was also evaluated. It is worth highlighting that the results of the cytotoxicity assays performed (MTT, DHI HoloMonitorM4) indicate high cell viability of the human fibroblast (VH10) in the presence of the Mn(II) complexes. Additionally, the inhibition effect of catalase activity by the complexes was studied. This paper focused on such aspects as studying different types of intermolecular interactions in the crystals of the Mn(II) complexes as well as their possible effect on anti-biofilm activity, the structure–activity relationship of the Mn(II) complexes, and regularity between the electrochemical properties of the Mn(II) complexes and anti-biofilm activity.

show abstract

Section: Description Of the Molecular And Crystal Structurementioning

confidence: 60%

Tuning Anti-Biofilm Activity of Manganese(II) Complexes: Linking Biological Effectiveness of Heteroaromatic Complexes of Alcohol, Aldehyde, Ketone, and Carboxylic Acid with Structural Effects and Redox Activity

Jabłońska-Wawrzycka

Rogala

Czerwonka

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The partial solubility of QM probably occurred due to its high ability to chelate Ca +2 and/or Mg +2 ions present in the culture medium by means of the nitrogen atom of the ring and oxygen of the CH 2 OH group, forming coordinated complexes of low solubility. The previous argument is based on the results of some investigations that deals with the formation of metal ion complexes with the ligand 2‐hydroxymethylpyridine, which has a similar chemical structure as QM …”

Section: Resultsmentioning

confidence: 99%

Nanoparticles of 4,7‐dichloro‐2‐quinolinemethylacrylate‐based copolymers and their potential cytotoxic activity on human breast carcinoma cells

Valle

Palao-Suay

Aguilar

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this article, an improved synthesis strategy of the potent anticancer compound 4,7-dichloro-2-quinolinemethanol (QM) and its acrylate ester 4,7-dichloro-2-quinolinemethylacrylate (AQM) are described. AQM is copolymerized using free-radical polymerization with N-vinyl-2-pyrrolidone (VP) and the copolymers obtained from different molar ratios of monomers are subjected to nanoprecipitation to produce suspensions of nanoparticles (NPs) in phosphate buffered saline (PBS). The smallest and stable NPs are prepared with the AQM-VP copolymers 45:55 and 40:60 (118.9 and 128.7 nm in diameter, respectively) at 1 mg mL −1 , and along with AQM and QM, are evaluated for their cytotoxic activity on MDA-MB-453 breast carcinoma cells using MTT bioassay. AQM and QM are highly cytotoxic (IC 50 : 19 and 41 μM, respectively); however, the NPs are not cytotoxic in the range of the assayed concentrations. These results contribute to the search for new polymeric NPs with potential application as QM delivery systems for the treatment of cancer or other diseases treatable with QM.There are several cellular internalization mechanisms that are influenced by the physicochemical properties of the NPs. These are phagocytosis, macropinocytosis, clathrin-mediated endocytosis, and caveolae-mediated endocytosis. With the exception of the last Additional Supporting Information may be found in the online version of this article.

show abstract

“…Tables and present the relative energy of each spin state for the different complexes and DFs. Experimental evidence shows that all these complexes are found in a high‐spin in their ground states, namely sextet for Mn(II) complexes ( 1 – 4 ) or quintet for Mn(III) ones ( 5 – 7 ) . Indeed, Mn‐complexese are usually found as high‐spin species.…”

Section: Resultsmentioning

confidence: 99%

“…Mangan‐oxo ( 6 ) and mangan‐peroxo ( 7 ) compounds have been additionally included, as such species are believed to be important reaction intermediates during water oxidation. For all these compounds, their spin state and structure have been experimentally determined …”

Section: Introductionmentioning

confidence: 99%

On the applicability of density functional theory to manganese‐based complexes with catalytic activity toward water oxidation

2017

View full text Add to dashboard Cite

The present contribution assesses the performance of several popular and accurate density functionals, namely B3LYP, BP86, M06, MN12L, mPWPW91, PBE0, and TPSSh toward manganese-based coordination complexes. These compounds show promising properties toward application to catalytic water oxidation. Although manganese with N- and O-biding ligands tends to give rise to high spin complexes, the results show that BP86, mPWPW91, and specially MN12L, tend to yield low-spin complexes. The usage of these functionals for such compounds is, thus, discouraged. All the functionals considered deliver accurate geometries. The present results show, however, that B3LYP delivers geometries deviating from experimental values when compared to the other functionals of the set. M06, PBE0, and TPSSh deliver geometries of similar accuracy, PBE0 outstanding slightly with respect to the other two. © 2017 Wiley Periodicals, Inc.

show abstract

Eight- and six-coordinated Mn(II) complexes of heteroaromatic alcohol and aldehyde: Crystal structure, spectral, magnetic, thermal and antibacterial activity studies

Cited by 22 publications

References 60 publications

Tuning Anti-Biofilm Activity of Manganese(II) Complexes: Linking Biological Effectiveness of Heteroaromatic Complexes of Alcohol, Aldehyde, Ketone, and Carboxylic Acid with Structural Effects and Redox Activity

Tuning Anti-Biofilm Activity of Manganese(II) Complexes: Linking Biological Effectiveness of Heteroaromatic Complexes of Alcohol, Aldehyde, Ketone, and Carboxylic Acid with Structural Effects and Redox Activity

Nanoparticles of 4,7‐dichloro‐2‐quinolinemethylacrylate‐based copolymers and their potential cytotoxic activity on human breast carcinoma cells

On the applicability of density functional theory to manganese‐based complexes with catalytic activity toward water oxidation

Contact Info

Product

Resources

About