Eight and a Half Syndrome from Multiple Sclerosis

Ahmed, Aiesha

doi:10.15406/jnsk.2015.03.00099

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Nine syndrome has also been named as an eight-and-a-half plus syndrome, and it can include hemiataxia. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Nine syndrome has also been named as an eight-and-a-half plus syndrome, and it can include hemiataxia. 6 Nine syndrome is a rare entity and there have been few cases reported in the literature till date, which are shown in Table 1. 3,[7][8][9][10][11] This syndrome comprises eight-and-a-half syndrome associated with hemiparesis and hemianesthesia due to additional involvement of the corticospinal tract and medial lemniscus.…”

Section: Discussionmentioning

confidence: 99%

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An unusual presentation of hemiparesis with complex ophthalmoplegia: A ‘nine’ syndrome

Jesuthasan

Getheeswaran

Pirasath

2022

SAGE Open Medical Case Reports

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Nine syndrome is a rare clinical entity with core clinical signs of one and a half syndrome, ipsilateral facial palsy, and contralateral hemiparesis/hemianesthesia and localizing to the dorsal paramedian pontine tegmentum. The awareness of this sign helps in precise localization and consideration of relevant aetiologies. Here, we report a case consisting of right horizontal gaze palsy with right internuclear opthalmoplegia and right lower motor neuron type VII nerve palsy constituting eight-and-a-half syndrome. With the additional involvement of left upper and lower limb upper motor neuron weakness, it revealed the lesion responsible for the ‘nine’ syndrome in magnetic resonance imaging of the brain. It is our purpose to highlight the genesis of this combination of clinical signs.

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“…Nine syndrome has also been named as an eight-and-a-half plus syndrome, and it can include hemiataxia. 6 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An unusual presentation of hemiparesis with complex ophthalmoplegia: A ‘nine’ syndrome

Jesuthasan

Getheeswaran

Pirasath

2022

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

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Sixteen syndrome: a rare presentation of central demyelination

2023

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This case illustrates two diagnostic challenges for clinicians: the rarely described sixteen syndrome and the relationship between tumour necrosis factor (TNF)-alpha inhibitors and central demyelination. Sixteen syndrome affects horizontal eye movements and the facial nerve bilaterally reflecting a lesion in the posterior pontine tegmentum, adjacent to the fourth ventricle. Given its rarity and complexity of clinical signs, this syndrome risks misdiagnosis and mismanagement. The relationship between TNF-alpha inhibitors and demyelination is a complex issue in which causality is yet to be established. This diagnostic challenge poses a management dilemma for clinicians.

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