EIF4A3 targeted therapeutic intervention in glioblastoma multiforme using phytochemicals from Indian medicinal plants – an integration of phytotherapy into precision onco-medicine

Kulavi, Sohini; Dhar, Debajit; Kamal, Izaz Monir; Chakrabarti, Saikat; Bandyopadhyay, Jaya

doi:10.1080/07391102.2024.2314257

Cited by 1 publication

(1 citation statement)

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“…Using Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA), binding free energy analyses, and docking scores assessed with GOLD, AutoDock4.2, LeDock, and other tools, we further examined the efficacy of the compounds on our shortlist. Several Withania-specific compounds from Withania somnifera and one dietary compound, thiamine from Castanea sativa, have shown good ADMET properties, significant binding affinity towards the EIF4A3, and relatively good blood-brain barrier permeability among the phytochemical studies, providing a chance to create medication candidates that target glioblastoma brought on by overexpression of EIF4A3 [174]. A recent study examined the cytotoxicity of hydromethanolic extracts of W. somnifera fruits (W-F) and roots (W-R) and their chromatographic fractions against three normal oral mesenchymal cells [human gingival fibroblast (HGF), human periodontal ligament fibroblast (HPLF), and human pulp cells (HPC)] as well as oral squamous cell carcinoma (OSCC) cell lines [Ca9-22 (derived from gingiva), HSC-2, HSC-3, and HSC-4 (derived from tongue)].…”

Section: Withania Somniferamentioning

confidence: 99%

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Albahri,

Badran,

Abdel Baki

et al. 2024

Pharmaceuticals

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Globally, cancer is one of the primary causes of both morbidity and mortality. To prevent cancer from getting worse, more targeted and efficient treatment plans must be developed immediately. Recent research has demonstrated the benefits of natural products for several illnesses, and these products have played a significant role in the development of novel treatments whose bioactive components serve as both chemotherapeutic and chemo-preventive agents. Phytochemicals are naturally occurring molecules obtained from plants that have potential applications in both cancer therapy and the development of new medications. These phytochemicals function by regulating the molecular pathways connected to the onset and progression of cancer. Among the specific methods are immune system control, inducing cell cycle arrest and apoptosis, preventing proliferation, raising antioxidant status, and inactivating carcinogens. A thorough literature review was conducted using Google Scholar, PubMed, Scopus, Google Patent, Patent Scope, and US Patent to obtain the data. To provide an overview of the anticancer effects of several medicinal plants, including Annona muricata, Arctium lappa, Arum palaestinum, Cannabis sativa, Catharanthus roseus, Curcuma longa, Glycyrrhiza glabra, Hibiscus, Kalanchoe blossfeldiana, Moringa oleifera, Nerium oleander, Silybum marianum, Taraxacum officinale, Urtica dioica, Withania somnifera L., their availability, classification, active components, pharmacological activities, signaling mechanisms, and potential side effects against the most common cancer types were explored.

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Section: Withania Somniferamentioning

confidence: 99%