EIF4A3-induced circFIP1L1 represses miR-1253 and promotes radiosensitivity of nasopharyngeal carcinoma

Zhou, Xiaoming; Yuan, Guang-Jin; Wu, Yangjie; Yan, Sijia; Jiang, Qingshan; Tang, Sanyuan

doi:10.1007/s00018-022-04350-x

Cited by 11 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported in previous publications, miR-1253 knockdown can suppress NPC cell viability, accelerate NPC cell apoptosis and enhance the radiosensitivity of NPC. Mechanistically, upstream circFIP1L1 suppressed the inhibitory effect of miR-1253 on EIF4A3 ( 16 ). Moreover, miR-7-5p can reduce the radiosensitivity of NPC cells by promoting cell proliferation and accelerating cell death through the upregulation of ENO2 ( 18 ).…”

Section: Resultsmentioning

confidence: 99%

“…Several scholars have identified and demonstrated the impact of miRNAs in adjusting the differential expression of functional genes on cell proliferation, invasion, apoptosis, migration, and even novel phenotypes in NPC against the background of radiation resistance and chemotherapy resistance (16)(17)(18)(19). Therefore, further exploration and validation of new miRNAs may lead to the identification of vital biomarkers or predictors for identifying radioresistant or chemo resistant patients in the clinic.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

Xu,

Li,

Wang

2024

Front. Oncol.

View full text Add to dashboard Cite

Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor that develops in the nasopharynx. It has a distinct ethnic and geographical distribution, and emerging evidence suggests that it is an ecological disease. Most patients respond well to radiation combined with chemotherapy as the primary treatment for NPC. However, some patients will eventually develop radio resistance and chemoresistance, resulting in recurrence and metastasis, which is a primary cause of poor prognosis. The processes underlying radio resistance and chemoresistance in NPC are complex and unknown. MicroRNAs (miRNAs) are endogenic non-coding RNA molecules. They play a role in a variety of cell functions as well as development of disease such as cancer. There has been considerable data demonstrating the existence of numerous aberrant miRNAs in cancer tissues, cells, and biofluids, which indicates the importance of studying the influence of miRNAs on NPC. Therefore, this review comprehensively analyzes the elaborate mechanisms of miRNAs affecting the radio resistance and chemoresistance of NPC. Multiple tumor-specific miRNAs can be employed as therapeutic and prognostic biological indicators.

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

Xu,

Li,

Wang

2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…METTL3 knockout decreased the stability of SOCS3, may owe to reduced m6A modi cations around their stop codons preferentially recognized and stabilized by IGF2BP1 [32][33][34] . Really, numerous studies suggest that IGF2BP1 selectively recognizes and promotes mRNA stability 35,36 . Our data demonstrated that m6A modi cation and SOCS3 are involved senescence of SkMSCs, suggesting that intervention of m6A modi cation and m6A might be a potential strategy for regulating cell senescence.…”

Section: Discussionmentioning

confidence: 99%

N6-methyladenosine-mediated changes in SOCS3 expression regulate skeletal muscle stem cell senescence

Zhu

Lian

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

N6-methyladenosine (m6A)-associated mechanisms are involved in cellular metabolic activities; however, their role in skeletal muscle stem cell (SkMSC) senescence is unknown. In this study, m6A RNA modification and METTL3 expression were decreased in aged SkMSCs from mice. Transcriptional analysis of m6A modification further revealed that suppressor of cytokine signaling 3 (SOCS3) was downregulated in aged SkMSCs, and that downregulation of METTL3 promoted SkMSC senescence. In addition, the upregulation of METTL3 alleviated the senescence of SkMSCs. Mechanistically, deletion of m6A modifications promoted senescence and inhibited SOCS3 expression, whereas downregulation of SOCS3 promoted senescence. Moreover, insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) was identified as an important regulator in the recognition and stabilization of m6A modified SOCS3 expression. IGF2BP1 binds to SOCS3 and reinforces its stability by suppressing the phosphorylation of JAK2/STAT3. Therefore, METTL3 inhibits SkMSC senescence through m6A modification-dependent stabilization of SOCS3 expression and inhibition of JAK2-STAT3 signaling. This study thus highlights a novel mechanism underlying SkMSC senescence.

show abstract

CircRNA amyloid precursor protein by competitive adsorption of microRNA-6838-5p mediates CDV3 expression to enhance malignant behavior and Warburg effect in Gastrointestinal Stromal Tumor

Wang,

Zeng,

Yuan

2024

Clinics

View full text Add to dashboard Cite

EIF4A3-induced circFIP1L1 represses miR-1253 and promotes radiosensitivity of nasopharyngeal carcinoma

Cited by 11 publications

References 42 publications

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

The promising role of miRNAs in radioresistance and chemoresistance of nasopharyngeal carcinoma

N6-methyladenosine-mediated changes in SOCS3 expression regulate skeletal muscle stem cell senescence

CircRNA amyloid precursor protein by competitive adsorption of microRNA-6838-5p mediates CDV3 expression to enhance malignant behavior and Warburg effect in Gastrointestinal Stromal Tumor

Contact Info

Product

Resources

About