Eidolon: Visualization and Computational Framework for Multi-modal Biomedical Data Analysis

Kerfoot, Eric; Fovargue, Lauren; Rivolo, Simone; Shi, Wenzhe; Rueckert, Daniel; Nordsletten, David; Lee, John; Chabiniok, Radomí­r; Razavi, Reza

doi:10.1007/978-3-319-43775-0_39

Cited by 12 publications

(12 citation statements)

References 12 publications

(10 reference statements)

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“…The visualization and analysis of the data was performed using the software package Eidolon (Kerfoot et al, 2016). Specifically, the motion of structures throughout the time-dependant image series was described via a motion tracking algorithm based on temporal sparse free-form deformations, where the deformation is reconstructed from an image sequence.…”

Section: Methodsmentioning

confidence: 99%

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy

et al. 2018

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Introduction: Atrial fibrillation (AF) is a widespread cardiac arrhythmia that commonly affects the left atrium (LA), causing it to quiver instead of contracting effectively. This behavior is triggered by abnormal electrical impulses at a specific site in the atrial wall. Catheter ablation (CA) treatment consists of isolating this driver site by burning the surrounding tissue to restore sinus rhythm (SR). However, evidence suggests that CA can concur to the formation of blood clots by promoting coagulation near the heat source and in regions with low flow velocity and blood stagnation.Methods: A patient-specific modeling workflow was created and applied to simulate thermal-fluid dynamics in two patients pre- and post-CA. Each model was personalized based on pre- and post-CA imaging datasets. The wall motion and anatomy were derived from SSFP Cine MRI data, while the trans-valvular flow was based on Doppler ultrasound data. The temperature distribution in the blood was modeled using a modified Pennes bioheat equation implemented in a finite-element based Navier-Stokes solver. Blood particles were also classified based on their residence time in the LA using a particle-tracking algorithm.Results: SR simulations showed multiple short-lived vortices with an average blood velocity of 0.2-0.22 m/s. In contrast, AF patients presented a slower vortex and stagnant flow in the LA appendage, with the average blood velocity reduced to 0.08–0.14 m/s. Restoration of SR also increased the blood kinetic energy and the viscous dissipation due to the presence of multiple vortices. Particle tracking showed a dramatic decrease in the percentage of blood remaining in the LA for longer than one cycle after CA (65.9 vs. 43.3% in patient A and 62.2 vs. 54.8% in patient B). Maximum temperatures of 76° and 58°C were observed when CA was performed near the appendage and in a pulmonary vein, respectively.Conclusion: This computational study presents novel models to elucidate relations between catheter temperature, patient-specific atrial anatomy and blood velocity, and predict how they change from SR to AF. The models can quantify blood flow in critical regions, including residence times and temperature distribution for different catheter positions, providing a basis for quantifying stroke risks.

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Section: Methodsmentioning

confidence: 99%

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy

et al. 2018

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“…The walls of the left ventricle were segmented using the medical image software Eidolon [16], and the LGE was delineated using a semi-automated full-width at half maximum technique. Tetrahedral meshes were created using CGAL [17].…”

Section: A Patient Mri Dataset and 3d Geometrical Modelingmentioning

confidence: 99%

3D Electrophysiological Modeling of Interstitial Fibrosis Networks and Their Role in Ventricular Arrhythmias in Non-Ischemic Cardiomyopathy

Balaban

Costa

Porter

et al. 2020

IEEE Trans. Biomed. Eng.

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Interstitial fibrosis is a pathological expansion of the heart's inter-cellular collagen matrix. It is a potential complication of nonischemic cardiomyopathy (NICM), a class of diseases involving electrical and or mechanical dysfunction of cardiac tissue not caused by atherosclerosis. Patients with NICM and interstitial fibrosis often suffer from life threatening arrhythmias, which we aim to simulate in this study. Methods: Our methodology builds on an efficient discrete finite element (DFE) method which allows for the representation of fibrosis as infinitesimal splits in a mesh. We update the DFE method with a local connectivity analysis which creates a consistent topology in the fibrosis network. This is particularly important in nonischemic disease due to the potential presence of large and contiguous fibrotic regions and therefore potentially complex fibrosis networks. Results: In experiments with an image-based model, we demonstrate that our methodology is able to simulate reentrant electrical events associated with cardiac arrhythmias. These reentries depended crucially upon sufficient fibrosis density, which was marked by conduction slowing at high pacing rates. We also created a 2D test-case which demonstrated that fibrosis topologies can modulate transient conduction block, and thereby reentrant activations. Conclusion: Ventricular arrhythmias due to interstitial fibrosis in NICM can be efficiently simulated using our methods in medical image based geometries. Furthermore, fibrosis topology modulates transient conduction block, and should be accounted for in electrophysiological simulations with interstitial fibrosis. Significance: Our study provides methodology which has the potential to predict arrhythmias and to optimize treatments noninvasively for nonischemic cardiomyopathies.

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“…Displacements from tagged MRI are extracted by using the Image Registration Toolkit library (IRTK) [18], implemented within the visualisation software Eidolon [10]. This provides full 3D displacement vectors u 3Dtag in the case of 3D tagged sequences, or their projection in the short-axis plane u SAtag for 2D tagged MR images.…”

Section: Assessment Based On Displacements Extracted From Tagged Mrimentioning

confidence: 99%

Cardiac Displacement Tracking with Data Assimilation Combining a Biomechanical Model and an Automatic Contour Detection

Chabiniok

Bureau

Groth

et al. 2019

Functional Imaging and Modeling of the Heart

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Data assimilation in computational models represents an essential step in building patient-specific simulations. This work aims at circumventing one major bottleneck in the practical use of data assimilation strategies in cardiac applications, namely, the difficulty of formulating and effectively computing adequate data-fitting term for cardiac imaging such as cine MRI. We here provide a proof-of-concept study of data assimilation based on automatic contour detection. The tissue motion simulated by the data assimilation framework is then assessed with displacements extracted from tagged MRI in six subjects, and the results illustrate the performance of the proposed method, including for circumferential displacements, which are not well extracted from cine MRI alone.

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Eidolon: Visualization and Computational Framework for Multi-modal Biomedical Data Analysis

Cited by 12 publications

References 12 publications

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy

3D Electrophysiological Modeling of Interstitial Fibrosis Networks and Their Role in Ventricular Arrhythmias in Non-Ischemic Cardiomyopathy

Cardiac Displacement Tracking with Data Assimilation Combining a Biomechanical Model and an Automatic Contour Detection

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