Eicosapentaenoic acid regulates IκBα and prevents tubulointerstitial injury in kidney

Takase, Osamu; Hishikawa, Keiichi; Kamiura, Nozomu; Nakakuki, Masanori; Kawano, Hiroyuki; Mizuguchi, Kiyoshi; Fujita, Toshiro

doi:10.1016/j.ejphar.2011.07.043

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…In the current study, we showed that linseed-enriched diet up-regulated the expression of genes ( SLC20A1 , TRAF3IP2 , TP53INP1 , TNFRSF12A , TLR9 and BIRC2 ) which involved in IκB inhibition in porcine skeletal muscle, and might lead to decrease NF-κB activation (Table 5 ). Recent studies indicated that activation of NF-κB is inhibited by n-3 PUFAs in lymphomonocyte [ 45 ], and the decreased IKK activation is likely to contribute to the suppressed NF-κB activation [ 46 ]. Our results provided an alternative explanation why n-3 PUFAs could suppress NF-κB activation.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs

Wei

Zhou

Jiang

et al. 2016

J Animal Sci Biotechnol

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BackgroundTo investigate the effect of feeding a linseed-enriched diet to growing-finishing pigs on gene expression in skeletal muscle, pigs were fed with a linseed-enriched diet for 0, 30, 60 and 90 d. Transcriptional profiles of longissimus dorsi muscle were measured using Affymetrix Genechip.ResultsResults showed that 264 genes were identified as differentially expressed genes (DEGs). The strongest transcriptional response was clearly observed at 30 d. DEGs were assigned to several main functional terms, including transcription, apoptosis, intracellular receptor-mediated signaling, muscle organ development, fatty acid metabolic process, cell motion, regulation of glucose metabolic process, spermatogenesis and regulation of myeloid cell differentiation. We also found that transcriptional changs of several transcription cofactors might contribute to n-3 PUFAs regulated gene expression. In addition, the increased expression of IGF-1, insulin signaling pathway and the metabolism of amino acids might involve in the muscle growth induced by feeding a linseed-enriched diet. The results also provide the new evidence that the expression changes of PTPN1, HK2 and PGC-1α might contribute to the regulation of insulin sensitivity by n-3 PUFAs.ConclusionsOur finding provided correlative evidence that feeding the linseed enriched diet affact expression of genes involved in insulin signaling pathway and the metabolism of amino acids.

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Section: Discussionmentioning

confidence: 99%

Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs

Wei

Zhou

Jiang

et al. 2016

J Animal Sci Biotechnol

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“…Based on this, we believe that the absent reduction in proteinuria was not due to insufficient DPP4 inhibition and GLP-1R stimulation but rather because of the robust degree of renal injury in which a reduction in macrophage infiltration alone was not sufficient to influence the disease course. Takase et al (35) used eicosapentaenoic acid (EPA) in the same model. Treatment with EPA significantly reduced CD68positive macrophage infiltration into the tubulointerstitial area, which was associated with the prevention of tubulointerstitial injury.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury

Higashijima

Tanaka

Yamaguchi

et al. 2015

American Journal of Physiology-Renal Physiology

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Dipeptidyl peptidase (DPP)-4 is an enzyme that cleaves and inactivates incretin hormones capable of stimulating insulin secretion from pancreatic β-cells. DPP-4 inhibitors are now widely used for the treatment of type 2 diabetes. Experimental studies have suggested a renoprotective role of DPP-4 inhibitors in various models of diabetic kidney disease, which may be independent of lowering blood glucose levels. In the present study, we examined the effect of DPP-4 inhibitors in the rat Thy-1 glomerulonephritis model, a nondiabetic glomerular injury model. Rats were injected with OX-7 (1.2 mg/kg iv) and treated with the DPP-4 inhibitor alogliptin (20 mg·kg(-1)·day(-1)) or vehicle for 7 days orally by gavage. Alogliptin significantly reduced the number of CD68-positive inflammatory macrophages in the kidney, which was associated with a nonsignificant tendency to ameliorate glomerular injury and reduce proteinuria. Another DPP-4 inhibitor, anagliptin (300 mg·kg(-1)·day(-1) mixed with food) and a glucagon-like peptide-1 receptor agonist, exendin-4 (10 mg/kg sc), similarly reduced CD68-positive macrophage infiltration to the kidney. Furthermore, ex vivo transmigration assays using peritoneal macrophages revealed that exendin-4, but not alogliptin, dose dependently reduced monocyte chemotactic protein-1-stimulated macrophage infiltration. These data suggest that DPP-4 inhibitors reduced macrophage infiltration directly via glucagon-like peptide-1-dependent signaling in the rat Thy-1 nephritis model and indicate that the control of inflammation by DPP-4 inhibitors is useful for the treatment of nondiabetic kidney disease models.

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“…5 An et al in 2009 showed that omega-3 supplement could reduce the upregulation of profibrotic, proinflammatory and prooxidant routes and modified tubulointersititial fibrosis [23]. In the study done by Takase et al in 2011 it was indicated that EPA blocked the development of tubulointersititial damage in models with Thy-1 nephritis and had inhibitory effects on inflammatory molecules by regulating IKBa in cultured renal cells [24]. The study that Abdou et al conductd in 2014 declared that omega-3 fatty acids prevented renal toxicity induced by lead in rats [25].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

Moghadamnia

Mokhtari

Khatamsaz

2016

Zahedan J Res Med Sci

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Background: Thioacetamide causes lipid and kidney dysfunction.Omega-3 unsaturated fatty acids prevent the progression of renal diseases. Objectives: This study aimed to assess the protective effects of omega-3 fish oil supplement on thioacetamide induced lipid and kidney dysfunction in male rats. Methods: In this experimental study, 42 male rats were divided into 6 groups of 7: control group sham group which received 0.4 mL olive oil as a solvent, Thioacetamide group receiving thioacetamide at a dose of 150 mg/kg once as intraperitoneal injection, Experimental groups of 1, 2 and 3 which received omega-3 fish oil supplement at the doses of 100, 200, 300 mg/kg orally for 3 months respectively and then they received thioacetamide at the dose of 150 mg/kg intraperitoneally for once. The levels of serum creatinine, BUN, total cholesterol, LDL, HDL, FBS, triglyceride, sodium and potassium were measured. The pathological changes of tissue samples of the kidneys were studied after hematoxylin-eosin staining. The data were analyzed by SPSS-18 software and using one way ANOVA and Tukey as post hoc test. Significant level was considered to be P < 0.05.

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Eicosapentaenoic acid regulates IκBα and prevents tubulointerstitial injury in kidney

Cited by 10 publications

References 48 publications

Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs

Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs

Anti-inflammatory role of DPP-4 inhibitors in a nondiabetic model of glomerular injury

The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

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