Eicosapentaenoic acid is associated with the attenuation of dysfunctions of mesenchymal stem cells in the abdominal aortic aneurysm wall

Kugo, Hirona; Enomoto, Hirofumi; Yanagimoto, Kenichi; Tanaka, Hiroki; Moriyama, Tatsuya; Zaima, Nobuhiro

doi:10.1039/d2fo01102f

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…However, studies of the distribution of EPA in the human aortic wall is very limited. We have previously reported that the distribution of EPA-PC in human AAA walls is similar to that of MSCsmarker positive cells and M2 macrophage-marker positive cells 14,15) . On the other hand, the distribution of EPA-PC is not similar to that of M1 macrophage-marker positive cells 15) .…”

Section: Discussionmentioning

confidence: 56%

“…In other words, diets containing less EPA have fewer protective effects against AAA. In EPA-rich diets, the distribution of EPA-PC is similar to that of both MSC-positive markers and M2 macrophages in the aortic wall of AAA model rats 13,14) . Similarity in the distribution between EPA-PC and M1 macrophages in the aortic wall has not been clearly observed 13) .…”

Section: Discussionmentioning

confidence: 72%

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Similar Distribution between EPA-containing Phosphatidylcholine and Mesenchymal Stem Marker Positive Cells in the Aortic Wall of Abdominal Aortic Aneurysm Model Rat Fed a Low-EPA Content Diet

Higashihara,

Enomoto,

Sumi

et al. 2024

J. Oleo Sci.

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jjocs cations 2) . However, no pharmaceuticals are currently available to prevent AAA dilation and/or rupture.Epidemiological studies have suggested that a Mediterranean diet, which is characterized by balanced nutrition, including fruits, vegetables, and fatty fish can prevent the development of AAA in smokers 3) . The consumption of fish and nuts has been reported to be associated with a reduced risk of abdominal aortic aneurysms 3,4) . Yamagishi et al. reported that individuals who consume fish once or twice a Abstract: Abdominal aortic aneurysm (AAA) is a vascular disease characterized by progressive dilation of the abdominal aorta. Previous studies have suggested that dietary components are closely associated with AAA. Among those dietary components, eicosapentaenoic acid (EPA) is considered to have suppressive effects on AAA. In the AAA wall of AAA model animals bred under EPA-rich condition, the distribution of EPA-containing phosphatidylcholine (EPA-PC) has been reported to be similar to that of the markers of mesenchymal stem cells (MSCs) and M2 macrophages. These data suggest that the suppressive effects of EPA on AAA are related to preferential distribution of specific cells in the aortic wall. However, the distribution of EPA-PC in the AAA wall of AAA model animals fed a diet containing small amounts of EPA, which has not been reported to inhibit AAA, has not yet been explored. In the present study, we visualized the distribution of EPA-PCs in the AAA wall of AAA model animals fed a diet containing small amounts of EPA (1.5% EPA in the fatty acid composition) to elucidate the vasoprotective effects of EPA. Positive areas for markers of MSCs were significantly higher in the region where EPA-PC was abundant compared to the regions where EPA-PC was weakly detected, but not for markers of M2 macrophages, matrix metalloproteinase (MMP)-2, and MMP-9. The distribution of MSC markers was similar to that of EPA-PC but not that of M2 macrophages and MMPs. These data suggest preferential incorporation of EPA into MSCs under the conditions used in this study. The incorporation of EPA into certain cells may differ according to dietary conditions, which affect the development of AAA.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 72%

Similar Distribution between EPA-containing Phosphatidylcholine and Mesenchymal Stem Marker Positive Cells in the Aortic Wall of Abdominal Aortic Aneurysm Model Rat Fed a Low-EPA Content Diet

Higashihara,

Enomoto,

Sumi

et al. 2024

J. Oleo Sci.

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“…This finding is consistent with Ezure and Amano who saw no difference in either cell abundance or ColIa1 expression compared to control as a function of EPA [31] . These data suggest that even though EPA may have anti-inflammatory effects in the cardiovascular system [32] , [33] , [34] and in patients with cancer [35] , the effect of EPA on the musculoskeletal system is less clear [36] , [37] .…”

Section: Discussionmentioning

confidence: 99%

Saturated fatty acids negatively affect musculoskeletal tissues in vitro and in vivo

Lin,

Osipov,

Steffen

et al. 2024

Matrix Biology Plus

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“…Low serum EPA levels and EPA/AA ratio were associated with the size and growth rate of AAA [121]. The protective effects and underlying mechanisms of EPA in AAA have been identified (Figure 4): (1) increased anti-inflammatory property of macrophages due to lessened inflammatory factor such as MMP2 and MMP9 levels [122][123][124] (2) attenuated of mesenchymal stem cell (MSC) dysfunctions [125] (3) suppressed the weakening of the vascular wall by inhibiting the elastin fiber degradation caused by nicotine [126] (4) inhibition of endothelial cell-mediated inflammatory factors [107]. AAA is associated with inflammation and oxidative stress, the latter of which contributes to activation of macrophages, a prominent cell type in AAA.…”

Section: Omega -3 Polyunsaturated Fatty Acidmentioning

confidence: 99%

Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications

Wang,

Yesitayi,

Liu

et al. 2023

Int. J. Biol. Sci.

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Aortic aneurysm and dissection (AAD) are a group of insidious and lethal cardiovascular diseases that characterized by seriously threatening the life and health of people, but lack effective nonsurgical interventions. Alterations in metabolites are increasingly recognized as universal features of AAD because metabolic abnormalities have been identified not only in arterial tissue but also in blood and vascular cells from both patients and animal models with this disease. Over the past few decades, studies have further supported this notion by linking AAD to various types of metabolites such as those derived from gut microbiota or involved in TCA cycle or lipid metabolism. Many of these altered metabolites may contribute to the pathogenesis of AAD. This review aims to illustrate the close association between body metabolism and the occurrence and development of AAD, as well as summarize the significance of metabolites correlated with the pathological process of AAD. This provides valuable insight for developing new therapeutic agents for AAD. Therefore, we present a brief overview of metabolism in AAD biology, including signaling pathways involved in these processes and current clinical studies targeting AAD metabolisms. It is necessary to understand the metabolic mechanisms underlying AAD to provides significant knowledge for AAD diagnosis and new therapeutics for treatment.

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Eicosapentaenoic acid is associated with the attenuation of dysfunctions of mesenchymal stem cells in the abdominal aortic aneurysm wall

Abstract: The distribution of eicosapentaenoic acid-containing phosphatidylcholine was similar to that of mesenchymal stem cells markers in the abdominal aortic aneurysm wall.

Cited by 4 publications

References 33 publications

Similar Distribution between EPA-containing Phosphatidylcholine and Mesenchymal Stem Marker Positive Cells in the Aortic Wall of Abdominal Aortic Aneurysm Model Rat Fed a Low-EPA Content Diet

Similar Distribution between EPA-containing Phosphatidylcholine and Mesenchymal Stem Marker Positive Cells in the Aortic Wall of Abdominal Aortic Aneurysm Model Rat Fed a Low-EPA Content Diet

Saturated fatty acids negatively affect musculoskeletal tissues in vitro and in vivo

Targeting metabolism in aortic aneurysm and dissection: from basic research to clinical applications

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