Eicosapentaenoic Acid and Platelet Function in Japanese

Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia.

“…This amount is similar to that consumed by some fish-eating populations, 30 but considerably less than the that consumed by Eskimos 31 or used in other studies of VLDL turnover. 22 Our results suggest that the partial substitution of modest amounts of marine oils for other fats in the diet through the consumption of seafood or fish-oil supplements is an efficient method of lowering plasma triglyceride levels in patients with primary hypertriglyceridemia associated with high rates of VLDL synthesis.…”

“…22 Our results suggest that the partial substitution of modest amounts of marine oils for other fats in the diet through the consumption of seafood or fish-oil supplements is an efficient method of lowering plasma triglyceride levels in patients with primary hypertriglyceridemia associated with high rates of VLDL synthesis. In addition to reducing plasma triglyceride concentrations, such a change may also have a beneficial effect on the hemostatic function, 30 " 35 which has recently been reported 36 to be hyperactive in hypertriglyceridemia.…”

Eicosapentaenoic Acid (EPA) Reduces Cardiovascular Events: Relationship with the EPA/Arachidonic Acid Ratio

“…This conclusion is supported by the findings of Kromann et al, who found that three of 1,800 Inuit living in the Upernavik district of Greenland died of myocardial infarction between 1950 and 1974, whereas the corresponding number of deaths among Danes during the same period was estimated to be approximately 40 14) . In Japan, a series of studies by Hirai et al found results matching those of Dyerberg et al In 1980, the blood fatty acid composition and platelet adhesiveness were compared between the residents of fishing and farming villages 15) , and subsequently, in 1985, the mortality among patients with cardiovascular disease (CVD) was examined 16) . The residents of the fishing villages exhibited significantly higher levels of blood EPA, DHA and AA and higher blood EPA/AA ratios.…”

Lipid profile and cardiovascular risk in two Amazonian populations

“…More recently, the National Cholesterol Education Program (NCEP III, USA) 4 published the recommendations for estimating absolute coronary risk, considering the total cholesterol level, age, HDL-C level, values of systolic and diastolic blood pressure, and smoking habit, with different scores for men and women.In the past decade, several studies suggested that a more active lifestyle and higher consumption of fish could be beneficial, because they resulted in a lower incidence of cardiovascular events, a better lipid profile, and a reduction in blood pressure and in thrombotic risk [5][6][7][8] .Among the Eskimos in Greenland and the Japanese of Kohama Island, lower levels of total cholesterol and triglycerides and an extremely low incidence of coronary heart disease were observed as compared with those in the populations living on the continent 9-11 .In Brazil, epidemiological data of the Ministry of Health for the City of Belém, in the State of Pará 12 , showed that mortality due to cardiovascular disease was the major cause of death in that city despite the proximity to rivers and forests, and the high consumption of fish and typical fruits in that region.This study aimed at comparing the cardiovascular risk of the urban population of Belém in the State of Pará with that of an Amazonian riverside population (village of Vigia) living mainly on fish and with very scarce contact with large urban centers. …”

“…In the past decade, several studies suggested that a more active lifestyle and higher consumption of fish could be beneficial, because they resulted in a lower incidence of cardiovascular events, a better lipid profile, and a reduction in blood pressure and in thrombotic risk [5][6][7][8] .…”