Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs

Davis, Michael S.; McCulloch, Sharron; Myers, Teresa; Freed, Arthur N.

doi:10.1016/s0034-5687(01)00317-6

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…Allergic asthma is a chronic disease accompanied with airway hyperresponsiveness (AHR) associated with bronchial inflammation [2], mucus protein overproduction in airway [3,4], chronic cough [5], airway obstruction [6,7] and elevated serum IgE [8]. The time course for asthmatic responses includes immediate asthmatic response (IAR), late asthmatic response (LAR), and airway inflammation [9].…”

Section: Introductionmentioning

confidence: 99%

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model

Lin

Chen

Chiang

et al. 2006

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model

Lin

Chen

Chiang

et al. 2006

International Immunopharmacology

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“…In a subject with significant alteration of respiratory function, achieving a blood CO 2 level below the apnea threshold might therefore be impossible. In addition, there are concerns regarding the effects of low CO 2 on bronchial reactivity and pulmonary circulation …”

Section: Introductionmentioning

confidence: 99%

Apnea induction for invasive lung function testing in infant olive baboons: Comparison of intravenous propofol versus hyperventilation

Ivanov

Wolf

Papin³

et al. 2017

J of Medical Primatology

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“…attributable to other factors (3,5,14,17,30,31). The difficulty in clearly demonstrating a late-phase response in humans stands in contrast to data derived from a canine model of peripheral airway cooling and desiccation, in which a late-phase response can be reliably measured (9,11). Given the consistency with which this animal model reproduces the comparable acute-phase response in humans (10), it seemed unlikely that the late-phase response could be unique to dogs.…”

mentioning

confidence: 99%

Modeling the acute- and late-phase responses to peripheral airway cooling and desiccation

Davis¹,

Royer²,

Payton

et al. 2002

Journal of Applied Physiology

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Acute bronchoconstriction after isocapnic hyperpnea can be produced in most asthmatic individuals. However, the existence of a late-phase response is less certain. We used a canine model of isocapnic hyperpnea to test the hypothesis that this discrepancy is due to differences in the challenge threshold for the responses. Acute-phase and late-phase bronchoconstriction was measured in nine dogs after peripheral airway exposure to unconditioned air. Additionally, bronchoalveolar lavage fluid (BALF) was obtained during the late-phase response. The acute-phase response was a polynomial function with a decreasing slope at higher challenges, whereas the late-phase response suggested that a minimum threshold of challenge severity was needed to produce late-phase bronchoconstriction. BALF leukocyte and eicosanoid concentrations had linear relationships with challenge severity. Our data support the hypothesis that acute- and late-phase posthyperpnea responses have different dose-response relationships, a fact that may explain the frequent lack of a late-phase response. However, our data suggest that mild inflammation can be induced with relatively lower challenge severity.

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Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs

Cited by 7 publications

References 32 publications

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model

Apnea induction for invasive lung function testing in infant olive baboons: Comparison of intravenous propofol versus hyperventilation

Modeling the acute- and late-phase responses to peripheral airway cooling and desiccation

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