Eicosanoids and the ischemic myocardium

Schrör, Karsten; Hohlfeld, Thomas

doi:10.1007/978-94-009-0475-0_10

Cited by 7 publications

(1 citation statement)

References 109 publications

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“…The significant decrease of NE release in LCC-treated hearts suggests that this substance is involved in LCCinduced cardioprotection. It is well known that prostacyclin is a tissue protective factor in myocardial ischemia (35) that has a beneficial influence on the reperfused ischemic myocardium (15,30). The significant reduction of prostacyclin release during reperfusion after LCC administration suggests a relationship between prostacyclin and cardioprotection in this model.…”

Section: Discussionmentioning

confidence: 77%

A new method of long-term preventive cardioprotection usingLactobacillus

Oxman

Shapira

Diver

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

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Potential long-term cardioprotection was investigated in an extensive experimental study. Lactobacillus cultivation components (LCC) were administered intravenously in anesthetized rats 1, 7, and 21 days before global ischemia (GI). GI was produced by full stop flow in isolated Langendorff-perfused hearts for 20 min and was followed by reperfusion. Control animals were injected with saline. LCC reduced reperfusion tachyarrhythmia significantly and improved functional recovery of the ischemized rat heart. These beneficial effects were associated with reduction of release of norepinephrine (NE) and prostacyclin at the first minute of reperfusion, activation of myocardial catalase, and overexpression of 70-kDa heat stress protein (HSP-70) at ischemia and reperfusion (P < 0.05). This cardioprotection was documented up to 21 days after a single injection of LCC. Thus Lactobacillus cultivation components are new nontoxic materials that produce marked long-term cardioprotection against ischemia-reperfusion damage. This effect is attributed to an activation of the cellular defense system, manifested by activation of the antioxidant pathway and by expression of protective proteins. NE is involved in this process, and the data also suggest a role for prostacyclin in this model of cardioprotection. The potential of LCC and related compounds working through similar mechanisms in the prevention and therapy of various ischemic heart syndromes should be explored.

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Section: Discussionmentioning

confidence: 77%

A new method of long-term preventive cardioprotection usingLactobacillus

Oxman

Shapira

Diver

et al. 2000

American Journal of Physiology-Heart and Circulatory Physiology

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Regulation of Prostaglandin Receptors in Myocardial Ischemia

Hohlfeld

1995

Mediators in the Cardiovascular System: Regional Ischemia

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Inotropic actions of eicosanoids

Schrör

Hohlfeld

1992

Basic Res Cardiol

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Eicosanoids (prostaglandins, leukotrienes, thromboxane A2 and other metabolites of C-20 polyunsaturated fatty acids) have numerous effects in the cardiovascular system. Direct inotropic actions have been repeatedly described, but appear in only very few cases to be due to direct modification of the inotropic state of the heart. Specific eicosanoid receptors have been identified on the surface of the sarcolemmal membrane. Signal transduction pathways in the cardiac myocyte involve the adenylate cyclase/cAMP system or stimulation of the phospholipase C/IP3 pathway. In general, concentrations of eicosanoids which affect myocardial contractility are higher as the response is less predictable than the effects on platelet function or vessel tone. Therefore, eicosanoid-induced extracardiac effects may be superimposed to more direct changes in the contractile state of the intact heart in vitro or in vivo. In contrast to non-failing hearts, there is a significant improvement of the contractile function in contractile failure ("stunning", ischemia, congestive heart failure) by vasodilating prostaglandins (e.g., PGI2). The mechanism of this action is still unknown.

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Eicosanoids and the ischemic myocardium

Cited by 7 publications

References 109 publications

A new method of long-term preventive cardioprotection usingLactobacillus

A new method of long-term preventive cardioprotection usingLactobacillus

Regulation of Prostaglandin Receptors in Myocardial Ischemia

Inotropic actions of eicosanoids

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