Eicosanoids and delayed graft function in human renal transplantation

Norio, Karri; Saareks, Virpi; Vapaatalo, Heikki; Mäkisalo, Heikki; Péré, P.; Lindgren, L.

doi:10.1016/s0041-1345(01)02089-9

Cited by 1 publication

(2 citation statements)

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“…There were 10 studies where the primary objective was to identify and diagnose DGF using novel objective methods [46,19,47,48,38,45,49,33,50,34]. Methods to diagnose DGF were based on histology of the allograft (n = 3) [38,49,45], urinary and serum biomarkers (n = 4) [48,33,47,50], genetics (n = 1) [34] or the use of imaging (n = 2) [46,19] (Table 2). All the studies were single center studies except one [33].…”

Section: Novel Methods For Diagnosis Of Dgfmentioning

confidence: 99%

“…The most promising newer methods to diagnose DGF were urine biomarkers (IL-18 and NGAL) [33,48] and the measurement of systemic and renal vein eicosanoids [47]. The advantages of these biomarkers are that it is noninvasive to obtain the urine or blood and also these biomarkers are elevated at early time points after renal injury (within a few hours).…”

Section: Newer Techniques For Diagnosing Dgfmentioning

confidence: 99%

See 1 more Smart Citation

Marked variation in the definition and diagnosis of delayed graft function: a systematic review

Yarlagadda

Coca

Garg

et al. 2008

Nephrology Dialysis Transplantation

339

263

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The utilization of heterogeneous clinical criteria to define DGF has certain limitations. It will lead to delayed and sometimes inaccurate diagnosis of DGF. Hence a diagnostic test that identifies DGF reliably and early is necessary. Heterogeneity, in the definitions used for DGF, hinders the evolution of a diagnostic technique to identify DGF, which requires a gold standard definition. We are in need of a new definition that is uniformly accepted across the kidney transplant community. The new definition will be helpful in promoting better communication among transplant professionals and aids in comparing clinical studies of diagnostic techniques to identify DGF and thus may facilitate clinical trials of interventions for the treatment of DGF.

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