Eicosanoid biosynthesis in an advanced deuterostomate invertebrate, the sea squirt (Ciona intestinalis)

Knight, John; Taylor, Graham W.; Wright, Peter E.; Clare, Anthony S.; Rowley, Andrew F.

doi:10.1016/s0005-2760(98)00153-2

Cited by 39 publications

(35 citation statements)

References 46 publications

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“…Resveratrol is a competitive inhibitor of cyclooxygenase and peroxidase activity of PHS in human erythroleukemia cells [85,86]. As far as PHS is concerned, both cyclooxygenase and peroxidase activities depend on ferriprotoporphyrin IX [87,88].…”

Section: C) Resveratrol Chemoprevention By Inhibition Of Lipid Mediatorsmentioning

confidence: 99%

“…Again, the prolonged lag phase of the cyclooxygenase reaction was indicative of a reduction of Fe(III) to Fe(II) [88,89]. The cyclooxygenase inhibition by resveratrol prevents the release of cyclooxygenase products such as prostaglandins and thromboxanes [86,[90][91][92][93][94][95]. The mechanism of PHS inhibition by resveratrol has yet to be firmly established because there has been published a contradictory study showing that resveratrol is a non-competitive inhibitor of the peroxidase activity of the first isoenzyme of PHS, PHS-1, which is constitutively expressed, but that resveratrol does not inhibit the cyclooxygenase activity of PHS-2 which is induced by mitogen and various stimuli [96].…”

Section: C) Resveratrol Chemoprevention By Inhibition Of Lipid Mediatorsmentioning

confidence: 99%

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Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

Delmas¹,

Lançon²,

Colin³

et al. 2006

CDT

347

223

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Section: C) Resveratrol Chemoprevention By Inhibition Of Lipid Mediatorsmentioning

confidence: 99%

Section: C) Resveratrol Chemoprevention By Inhibition Of Lipid Mediatorsmentioning

confidence: 99%

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

Delmas¹,

Lançon²,

Colin³

et al. 2006

CDT

347

223

View full text Add to dashboard Cite

“…Constitutively active Cox-I was selectively inhibited with 1 pM or 10 pM resveratrol (Cayman Chemical, Ann Arbor, MI) [14,31,36]. Resveratrol can also inhibit the inducible form of the enzyme by suppressing Cox-2 mRNA production [59], although this requires higher levels of resveratrol.…”

Section: Role Of' Prostaglandin In the Pemf Responsementioning

confidence: 99%

Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells

Lohmann

Schwartz

Liu

et al. 2003

Journal Orthopaedic Research

119

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Osteocytes, the predominant cells in bone, are postulated to be responsible for sensing mechanical and electrical stimuli, transducing signals via gap junctions. Osteocytes respond to induced shear by increasing connexin 43 (Cx43) levels, suggesting that they might be sensitive to physical stimuli like low-frequency electromagnetic fields (EMF). Immature osteoblasts exhibit decreased intercellular communication in response to EMF but no change in Cx43. Here, we examined long term effects of pulsed EMF (PEMF) on MLO-Y4 osteocyte-like cells and ROS 17/23 osteoblast-like cells. In MLO-Y4 cell cultures, PEMF for 8 h/day for one, two or four days increased alkaline phosphatase activity but had no effect on cell number or osteocalcin. Transforming growth factor beta-1 (TGF-PI) and prostaglandin EZ were increased, and NO2-was altered. PEMFs effect on TGF-Pl was via a prostaglandin-dependent mechanism involving Cox-1 but not Cox-2. In ROS 17/2.X cells, PEMF for 24, 4X or 72 h did not affect cell number, osteocalcin mRNA or osteocalcin protein. PEMF reduced Cx43 protein in both cells. Longer exposures decreased Cx43 mRNA. This indicates that cells in the osteoblast lineage, including well-differentiated osteoblast-like ROS 17/23 cells and terminally differentiated osteocyte-like MLO-Y4 cells, respond to PEMF with changes in local factor production and reduced Cx43, suggesting decreased gap junctional signaling.

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“…Our data showing the inhibitory effects of both esculetin and NDGA on BMSF synthesis are consistent with the involvement of a lipoxygenase as one of these steps. The presence of 8-lipoxygenase activity is common in aquatic invertebrates including corals (Bundy et al, 1986;Brash et al, 1996), starfish (Meijer et al, 1986), crabs (Hampson et al, 1992), sea squirts (Knight et al, 1999) and barnacles (Vogan et al, 2003). Such reports have shown that the hydroperoxides formed have an R rather than the S configuration, which is largely characteristic of vertebrate lipoxygenases (Brash et al, 1996;Schneider and Brash, 2002).…”

Section: P450mentioning

confidence: 99%

The identification and role of a novel eicosanoid in the reproductive behaviour of barnacles (Balanus balanus)

Maskrey

Taylor

Rowley

2006

Journal of Experimental Biology

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SUMMARY Post-copulatory behaviour in barnacles involves a violent rocking movement of the opercular valves, which is thought to contribute to the expulsion of oocytes through the oviduct into the mantle cavity where they are fertilised. We demonstrate in this study that the seminal vesicles/testis of the subtidal barnacle Balanus balanus produce a biologically active factor,barnacle muscle stimulatory factor (BMSF), which causes a significant increase in cirral and body muscular activity. BMSF was identified using a combination of high performance liquid chromatography and mass spectrometry as a novel eicosanoid/oxylipin, 8,13-dihydroxyeicosapentaenoic acid. This is rapidly inactivated under mild acid conditions to form a complex range of triene and pentaene chromophore-containing products that have only been partially identified. Injection of purified BMSF into the mantle cavity of barnacles caused the rocking movements of the opercular valves as reported following fertilisation. In excised barnacles, it also caused muscular contractions of the whole body mass. The breakdown products of BMSF, however, were without such activities. The function of BMSF in facilitating fertilisation in barnacles is comparable to the role of other eicosanoids in human reproduction, reinforcing the view that these compounds have conserved activities in both invertebrates and vertebrates.

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Eicosanoid biosynthesis in an advanced deuterostomate invertebrate, the sea squirt (Ciona intestinalis)

Cited by 39 publications

References 46 publications

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells

The identification and role of a novel eicosanoid in the reproductive behaviour of barnacles (Balanus balanus)

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