Ehrlichiosis and Anaplasmosis

Diniz, Pedro; Aguiar, Daniel Moura de

doi:10.1016/j.cvsm.2022.07.002

Cited by 8 publications

(2 citation statements)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Members of the family Anaplasmataceae (Order: Rickettsiales) are obligate intracellular bacteria that can infect a wide range of animals [ 10 , 36 ]. Historically, two genera, Anaplasma and Ehrlichia , have been described as important tick-borne bacteria of public and veterinary health interest [ 1 , 3 , 11 , 12 , 18 , 33 ]. These genera include Anaplasma phagocytophilum and Ehrlichia chaffeensis that cause human granulocytic anaplasmosis and human monocytic ehrlichiosis, respectively and Ehrlichia ruminantium that causes heartwater (cowdriosis) in African cattle [ 1 , 11 , 12 , 18 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

“…Historically, two genera, Anaplasma and Ehrlichia , have been described as important tick-borne bacteria of public and veterinary health interest [ 1 , 3 , 11 , 12 , 18 , 33 ]. These genera include Anaplasma phagocytophilum and Ehrlichia chaffeensis that cause human granulocytic anaplasmosis and human monocytic ehrlichiosis, respectively and Ehrlichia ruminantium that causes heartwater (cowdriosis) in African cattle [ 1 , 11 , 12 , 18 , 33 ]. Recent advances in the genomics of these major pathogens have shed new light on the intracellular lifestyle of Anaplasmataceae and the mechanisms by which they induce and evade the innate immune response [ 2 , 15 , 17 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diversity and phylogeny of the tick-borne bacterial genus Candidatus Allocryptoplasma (Anaplasmataceae)

Ouass,

Boulanger,

Lelouvier

et al. 2023

Parasite

View full text Add to dashboard Cite

The family Anaplasmataceae includes tick-borne bacteria of major public and veterinary health interest, as best illustrated by members of the genera Anaplasma and Ehrlichia. Recent epidemiological surveys have also reported on the presence of a novel putative genus in the Anaplasmataceae, Candidatus Allocryptoplasma, previously described as Candidatus Cryptoplasma in the western black-legged tick, Ixodes pacificus. However, the genetic diversity of Ca. Allocryptoplasma and its phylogenetic relationship with other Anaplasmataceae remain unclear. In this study, we developed a multi-locus sequence typing approach, examining the DNA sequence variation at five genes of Ca. Allocryptoplasma found in ticks. Combining this multi-locus sequence typing and genetic data available on public databases, we found that substantial genetic diversity of Ca. Allocryptoplasma is present in Ixodes, Amblyomma and Haemaphysalis spp. ticks on most continents. Further analyses confirmed that the Ca. Allocryptoplasma of ticks, the Ca. Allocryptoplasma of lizards and some Anaplasma-like bacteria of wild mice cluster into a monophyletic genus, divergent from all other genera of the family Anaplasmataceae. Candidatus Allocryptoplasma appears as a sister genus of Anaplasma and, with the genera Ehrlichia and Neoehrlichia, they form a monophyletic subgroup of Anaplasmataceae associated with tick-borne diseases. The detection of genetically distinct Ca. Allocryptoplasma in ticks of significant medical or veterinary interest supports the hypothesis that it is an emergent genus of tick-borne pathogens of general concern.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diversity and phylogeny of the tick-borne bacterial genus Candidatus Allocryptoplasma (Anaplasmataceae)

Ouass,

Boulanger,

Lelouvier

et al. 2023

Parasite

View full text Add to dashboard Cite

show abstract

Molecular identification, risk factor assessment, and phylogenetic analysis of tick-borne pathogens in symptomatic and asymptomatic cattle from South-Eastern Iran

Fathi,

Nabavi,

Noaman

et al. 2024

Exp Appl Acarol

View full text Add to dashboard Cite

Detection of Anaplasma spp. and Ehrlichia spp. in dogs from a veterinary teaching hospital in Italy: a retrospective study 2012–2020

Facile,

Sabetti,

Balboni

et al. 2024

Vet Res Commun

View full text Add to dashboard Cite

Anaplasma phagocytophilum, Anaplasma platys and Ehrlichia canis, responsible of diseases in dogs, are tick-borne pathogens with a proven or potential zoonotic role that have shown increasing prevalence worldwide. The aims of this retrospective study were to assess the frequency of Anaplasma spp. and Ehrlichia spp. exposure in dogs tested in a veterinary teaching hospital in Italy over a 9-year period, to compare the performance of the diagnostic tests used, to evaluate correlations with clinical data, and to genetically analyse the identified bacteria. During the study period, 1322 dogs tested by at least one of the rapid immunoenzymatic test, indirect immunofluorescent antibody test or end-point PCR assay for Anaplasmataceae detection were included. Dogs were tested if they had clinical signs or clinicopathological alteration or risk factors related to infection, and if they were potential blood-donor animals. Ninety-four of 1322 (7.1%) dogs tested positive for at least one pathogen: 53 (4.3%) for A. phagocytophilum, one (0.1%) for A. platys and 63 (4.6%) for E. canis. The number of dogs tested increased and the positivity rate progressively declined over the years. Comparison of tests showed a near-perfect agreement between serological tests and a poor agreement between PCR and indirect assays. A breed predisposition has been highlighted for A. phagocytophilum infection in hunting breed dogs and for E. canis infection in mixed breed dogs. Phylogeny confirmed potential zoonotic implications for A. phagocytophilum and showed no correlation of the identified bacteria with the geographical origin. Our study provides new insights into possible risk factors in dogs and evidenced discordant results between different tests, suggesting that a combination of serological and molecular assays is preferable for a correct diagnosis.

show abstract

Ehrlichiosis and Anaplasmosis

Cited by 8 publications

References 192 publications

Diversity and phylogeny of the tick-borne bacterial genus Candidatus Allocryptoplasma (Anaplasmataceae)

Diversity and phylogeny of the tick-borne bacterial genus Candidatus Allocryptoplasma (Anaplasmataceae)

Molecular identification, risk factor assessment, and phylogenetic analysis of tick-borne pathogens in symptomatic and asymptomatic cattle from South-Eastern Iran

Detection of Anaplasma spp. and Ehrlichia spp. in dogs from a veterinary teaching hospital in Italy: a retrospective study 2012–2020

Contact Info

Product

Resources

About