Abstract:Background and aims Calcitonin gene-related peptide (CGRP) and glyceryl trinitrate (GTN) infusion in migraineurs provokes headache resembling spontaneous migraine. GTN infusion model was transformed to rats causing expression of protein markers as a surrogate for headache. We hypothesized that CGRP infusion in awake rats would increase molecular markers of neuronal activation in migraine relevant tissues.
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