EHMTI-0117. CGRP infusion in awake rats does not increase expression of immediate early genes, c-fos and zif268, in the trigeminal nucleus caudalis

Abstract

Background and aims Calcitonin gene-related peptide (CGRP) and glyceryl trinitrate (GTN) infusion in migraineurs provokes headache resembling spontaneous migraine. GTN infusion model was transformed to rats causing expression of protein markers as a surrogate for headache. We hypothesized that CGRP infusion in awake rats would increase molecular markers of neuronal activation in migraine relevant tissues.