Egyptian herbal tea infusions' antioxidants and their antiproliferative and cytotoxic activities against cancer cells

Elansary, Hosam O.; Mahmoud, Eman A.

doi:10.1080/14786419.2014.951354

Cited by 37 publications

(37 citation statements)

References 16 publications

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“…Several roots extracts from Linum usitatissimum significantly inhibited the growth of Jeg3 trophoblast tumor cells (Abarzua et al, 2007). Infusions from Mentha spp., Rosmarinus officinalis and Origanum majorana inhibited the growth of several cancer cell lines, including HeLa, Jurkat and MCF-7 (Elansary and Mahmoud, 2015). Seed oil isolated from Ecbalium elaterium inhibited the growth of HT-29 colonic adenocarcinoma (IC 50 = 4.86 μg/mL) and HT-1080 colonic fibrosarcoma cells (IC 50 = 4.16 μg/mL; Touihri et al, 2015).…”

Section: Scientific Evidence On Medicinal Plants Not Traditionally Usmentioning

confidence: 99%

North African Medicinal Plants Traditionally Used in Cancer Therapy

et al. 2017

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Background: Cancer is a major cause of mortality worldwide with increasing numbers by the years. In North Africa, the number of cancer patients is alarming. Also shocking is that a huge number of cancer patients only have access to traditional medicines due to several factors, e.g., economic difficulties. In fact, medicinal plants are widely used for the treatment of several pathologies, including cancer. Truthfully, herbalists and botanists in North African countries prescribe several plants for cancer treatment. Despite the popularity and the potential of medicinal plants for the treatment of cancer, scientific evidence on their anticancer effects are still scarce for most of the described plants.Objective: Bearing in mind the lack of comprehensive and systematic studies, the aim of this review is to give an overview of studies, namely ethnobotanical surveys and experimental evidence of anticancer effects regarding medicinal plants used in North Africa for cancer therapy.Method: The research was conducted on several popular search engines including PubMed, Science Direct, Scopus and Web of Science. The research focused primarily on English written papers published between the years 2000 and 2016.Results: This review on plants traditionally used by herbalists in North Africa highlights that Morocco and Algeria are the countries with most surveys on the use of medicinal plants in folk medicine. Among the plethora of plants used, Nigella sativa and Trigonella foenum-graecum are the most referred ones by herbalists for the treatment of cancer. Moreover, a plethora of scientific evidence qualifies them as candidates for further drug development. Furthermore, we report on the underlying cellular and molecular mechanisms.Conclusion: Overall, this review highlights the therapeutic potential of some medicinal plants as anticancer agents. The North African flora offers a rich source of medicinal plants for a wide array of diseases, including cancer. The elucidation of their modes of action represents an indispensable condition for the rational development of new drugs for cancer treatment. Furthermore, testing the anticancer activity in vivo and in clinical trials are warranted to explore the full therapeutic potential of North African plants for cancer therapy.

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Section: Scientific Evidence On Medicinal Plants Not Traditionally Usmentioning

confidence: 99%

North African Medicinal Plants Traditionally Used in Cancer Therapy

et al. 2017

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“…The R. officinalis essential oil obtained by steam distillation from the leaves (up to 2.5%), which are the most responsible for its biological activity. The main constituents are: camphor (5.0-21%), 1,8-cineole (15-55%), α-pinene (9.0-26%), borneol, camphene, β-pinene, and limonene in changing proportions, depending on growth stage and bioclimatic conditions [18]. Major polyphenols confirmed in R. officinalis leaf extracts, are flavonoids: apigenin, luteolin, nepetin, nepitrin, and phenolic acids: rosmarinic acid (c.a.…”

Section: Introductionmentioning

confidence: 99%

Saudi Rosmarinus officinalis and Ocimum basilicum L. Polyphenols and Biological Activities

et al. 2020

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Investigating the polyphenolic profile of natural Rosmarinus officinalis and Ocimum basilicum populations may reveal essential compounds that have biological activities. Natural populations of R. officinalis and O. basilicum in Northern Riyadh were investigated by HPLC-DAD analyses. Several polyphenols, including rosmarinic acid, gentisic acid, 3,4-dihydroxyphenylacetic acid, rutoside, and others, out of 38 screened were confirmed. Rosmarinic acid was the major polyphenol in both of R. officinalis and O. basilicum. R. officinalis methanolic leaf extracts contained other phenols such as gentisic acid while O. basilicum contained also 3,4-dihydroxyphenylacetic acid and rutoside as well as others. R. officinalis showed higher antioxidant activities than O. basilicum using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and β-carotene bleaching assays. These higher activities are associated with a higher composition of rosmarinic acid in leaf extracts. The antioxidant activities of O. basilicum were attributed to identified phenols of rosmarinic acid, 3,4-dihydroxyphenylacetic acid, and rutoside. There were antiproliferative and cytotoxic activities of leaf extracts, as well as identified polyphenols, against several cancer cells. These activities were attributed to the accumulation of necrotic and apoptotic cells in treated cancer cells with leaf extracts as well as identified polyphenols. The antibacterial and antifungal activities of leaf extracts were mainly attributed to 3,4-dihydroxyphenylacetic acid and rutoside in O. basilicum and rosmarinic acid and caffeic acid in R. officinalis. This study proved that R. officinalis and O. basilicum natural populations might be considered as promising sources of natural polyphenols with biological activities.

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“…These are combined with cytotoxic and genotoxic activities on the bovine leukemia virus-transformed lamb kidney fibroblasts. Mentha leaf extracts were studied for pro-apoptotic properties and cell cycle arrest of tumor cells (HeLa, MCF-7, Jurkat, T24, HT-29, MIAPaCa-2) (Jain et al 2011;Elansary & Mahmoud, 2015).…”

Section: Antiproliferative Propertiesmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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Egyptian herbal tea infusions' antioxidants and their antiproliferative and cytotoxic activities against cancer cells

Cited by 37 publications

References 16 publications

North African Medicinal Plants Traditionally Used in Cancer Therapy

North African Medicinal Plants Traditionally Used in Cancer Therapy

Saudi Rosmarinus officinalis and Ocimum basilicum L. Polyphenols and Biological Activities

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

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