EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy

Yang, Hung-Wei; Lu, Yu-Jen; Lin, Kun‐Ju; Hsu, Sheng-Chieh; Huang, Chiung-Yin; She, Shu-Han; Liu, Hao-Li; Lin, Chen-Hsuan; Xiao, Min-Cong; Wey, Shiaw-Pyng; Chen, Pin-Yuan; Yen, Tzu‐Chen; Wei, Kuo‐Chen; Chen‐Chi, M.

doi:10.1016/j.biomaterials.2013.06.007

Cited by 135 publications

(75 citation statements)

References 30 publications

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“…Previous studies demonstrated that Cur can significantly inhibit the proliferation of glioma cells by downregulating multidrug resistance proteins that cause the efflux of many chemotherapeutic agents. 28,29 However, its clinical application is severely restricted due to its low water solubility.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Zheng

Gao

Liu

et al. 2016

IJN

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Curcumin (Cur), a natural polyphenol of Curcuma longa , has been recently reported to possess antitumor activities. However, due to its poor aqueous solubility and low biological availability, the clinical application of Cur is quite limited. The encapsulation of hydrophobic drugs into nanoparticles is an effective way to improve their pharmaceutical activities. In this research, nanomicelles loaded with Cur were formulated by a self-assembly method with biodegradable monomethoxy poly(ethylene glycol)-poly(lactide) copolymers (MPEG-PLAs). After encapsulation, the cellular uptake was increased and Cur could be released from MPEG-PLA micelles in a sustained manner. The Cur-loaded MPEG-PLA micelles (Cur/MPEG-PLA micelles) exhibited an enhanced toxicity on C6 and U251 glioma cells and induced more apoptosis on C6 glioma cells compared with free Cur. Moreover, the therapy efficiency of Cur/MPEG-PLA micelles was evaluated at length on a nude mouse model bearing glioma. The Cur/MPEG-PLA micelles were more effective on suppressing tumor growth compared with free Cur, which indicated that Cur/MPEG-PLA micelles improved the antiglioma activity of Cur in vivo. The results of immunohistochemical and immunofluorescent analysis indicated that the induction of apoptosis, antiangiogenesis, and inhibition of cell proliferation may contribute to the improvement in antiglioma effects. Our data suggested that Cur/MPEG-PLA may have potential clinic applications in glioma therapy.

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Section: Discussionmentioning

confidence: 99%

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Zheng

Gao

Liu

et al. 2016

IJN

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“…Meanwhile, anticancer agents as well as therapeutic genes (e.g., DNA or siRNA) could be loaded in inorganic nanocarriers to achieve synergistic therapeutic effects due to their ease of surface modification (Figure 2A) 66. Moreover, inorganic nanocarriers could provide multifunctional platforms for cancer treatment, such as hyperthermia therapy,67, 68 which demonstrated potential to reverse MDR in cancers by combination with chemotherapy 69. More importantly, these inorganic nanocarriers could also provide molecular imaging function, which could help monitoring drug delivery processes and therapeutic outcomes, leading to improved treatment efficacy, especially for treating MDR cancers 70, 71…”

Section: Inorganic Nanocarriers Overcoming Drug Resistance For Cancermentioning

confidence: 99%

“…In addition, with high absorption in the NIR region, the GOs could be applied for tumor ablation by PTT. Thus, the drug‐loaded GOs were dual functionalized for chemotherapy and PTT to achieve synergistic effects, demonstrating a promising strategy to treat MDR cancers 69, 123, 124…”

Section: Inorganic Nanocarriers Overcoming Drug Resistance For Cancermentioning

confidence: 99%

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

et al. 2016

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Cancer multidrug resistance (MDR) could lead to therapeutic failure of chemotherapy and radiotherapy, and has become one of the main obstacles to successful cancer treatment. Some advanced drug delivery platforms, such as inorganic nanocarriers, demonstrate a high potential for cancer theranostic to overcome the cancer‐specific limitation of conventional low‐molecular‐weight anticancer agents and imaging probes. Specifically, it could achieve synergetic therapeutic effects, demonstrating stronger killing effects to MDR cancer cells by combining the inorganic nanocarriers with other treatment manners, such as RNA interference and thermal therapy. Moreover, the inorganic nanocarriers could provide imaging functions to help monitor treatment responses, e.g., drug resistance and therapeutic effects, as well as analyze the mechanism of MDR by molecular imaging modalities. In this review, the mechanisms involved in cancer MDR and recent advances of applying inorganic nanocarriers for MDR cancer imaging and therapy are summarized. The inorganic nanocarriers may circumvent cancer MDR for effective therapy and provide a way to track the therapeutic processes for real‐time molecular imaging, demonstrating high performance in studying the interaction of nanocarriers and MDR cancer cells/tissues in laboratory study and further shedding light on elaborate design of nanocarriers that could overcome MDR for clinical translation.

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“…[7][8][9] Other limitations of BCNU and temozolomide include their poor solubility, systemic toxicity, and short half-life in the human body. To date, many approaches have been proposed to improve the therapeutic effects of BCNU and enhance its stability, including polymeric nanoparticles (NPs), polymer biochips, magnetic NPs, graphene oxide, and liposomes, [10][11][12][13][14] but their safety and biocompatible issues still remain unclear. Albumin is the most abundant protein with a molecular weight of 66.5 kDa in plasma (35-50 g/L human serum), which is stable in a wide pH range (pH 4-9), biocompatible, biodegradable, nontoxic, and nonimmunogenic.…”

Section: Introductionmentioning

confidence: 99%

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents

Wei

Lin

Huang

et al. 2016

IJN

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To date, knowing how to identify the location of chemotherapeutic agents in the human body after injection is still a challenge. Therefore, it is urgent to develop a drug delivery system with molecular imaging tracking ability to accurately understand the distribution, location, and concentration of a drug in living organisms. In this study, we developed bovine serum albumin (BSA)-based nanoparticles (NPs) with dual magnetic resonance (MR) and fluorescence imaging modalities (fluorescein isothiocyanate [FITC]-BSA-Gd/1,3-bis(2-chloroethyl)-1-nitrosourea [BCNU] NPs) to deliver BCNU for inhibition of brain tumor cells (MBR 261-2). These BSA-based NPs are water dispersible, stable, and biocompatible as confirmed by XTT cell viability assay. In vitro phantoms and in vivo MR and fluorescence imaging experiments show that the developed FITC-BSA-Gd/BCNU NPs enable dual MR and fluorescence imaging for monitoring cellular uptake and distribution in tumors. The T1 relaxivity (R1) of FITC-BSA-Gd/BCNU NPs was 3.25 mM −1 s −1 , which was similar to that of the commercial T1 contrast agent (R1 =3.36 mM −1 s −1 ). The results indicate that this multifunctional drug delivery system has potential bioimaging tracking of chemotherapeutic agents ability in vitro and in vivo for cancer therapy.

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EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy

Cited by 135 publications

References 30 publications

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents

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EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy

Cited by 135 publications

References 30 publications

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and in vivo

Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance&ndash;fluorescence imaging for tracking of chemotherapeutic agents

Contact Info

Product

Resources

About

1,3-Bis(2-chloroethyl)-1-nitrosourea-loaded bovine serum albumin nanoparticles with dual magnetic resonance–fluorescence imaging for tracking of chemotherapeutic agents