Abstract:Background: Sevoflurane inhalation initiated cognitive deficits implicated in mitochondrial dysfunction, synaptogenesis impairment and neuroinflammation. Egr2 plays a crucial role in maintaining cognitive function. Therefore, we attempted to clarify the potential correlation regarding Egr2 expression and cognitive deficits induced by sevoflurane administration. Methods: Animals received sevoflurane anesthesia, and the behavioral tests including Morris water maze, novel object recognition test and trace fear co… Show more
“…Early growth response protein 2 (ERG2) dysregulation could lead to multiple phenotypes displayed by patient iAs as it has been proposed to play a role in dendritic complexity, cognition, and maintenance of mitochondrial membrane potential. 57 Moreover, defects in this gene are associated with Charcot-Marie-Tooth disease. 58,59 Similarly, upregulation of AKT serine/threonine kinase 3 and neuregulin-2 can be detrimental to mitochondrial function 60,61 or neuronal development, 62 respectively.…”
“…Early growth response protein 2 (ERG2) dysregulation could lead to multiple phenotypes displayed by patient iAs as it has been proposed to play a role in dendritic complexity, cognition, and maintenance of mitochondrial membrane potential. 57 Moreover, defects in this gene are associated with Charcot-Marie-Tooth disease. 58,59 Similarly, upregulation of AKT serine/threonine kinase 3 and neuregulin-2 can be detrimental to mitochondrial function 60,61 or neuronal development, 62 respectively.…”
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